Results 51 to 60 of about 1,348,172 (305)

Comparison of Direct Multiobjective Optimization Methods for the Design of Electric Vehicles [PDF]

, 2006
"System design oriented methodologies" are discussed in this paper through the comparison of multiobjective optimization methods applied to heterogeneous devices in electrical engineering.
Régnier, Jérémi, Sareni, Bruno, Roboam, Xavier, Fefermann, Yan   +3 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Combined domain knowledge and simplified model method for worst-case analysis of deck girder under multiple patch loads

Zhongguo Jianchuan Yanjiu
ObjectiveThis paper proposes a method for improving the efficiency and accuracy of finding the worst-case positions of wheel patch loads on deck grillage.
xiangyun LUO, Jun LIU, Puyu JIANG, yuansheng CHENG   +3 more
doaj   +1 more source

Efficient Local Search in Imaging Optimization Problems with a Hybrid Evolutionary Algorithm [PDF]

Journal of Systemics, Cybernetics and Informatics, 2005
The paper focuses on the efficiency of local search in a Hybrid evolutionary algorithm (HEA), with application to optimization problem frequently encountered in electronic imaging.
Igor Maslov
doaj  

Population-based methods in the optimization of stand management

Silva Fennica, 2009
In Finland, the growth and yield models for tree stands are simulation programs that consist of several sub-models. These models are often non-smooth and non-differentiable.
Pukkala, Timo
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Search for WIMPs at future μ + μ + colliders

Journal of High Energy Physics
Weakly interacting massive particles (WIMPs) with electroweak charges, such as the wino and the Higgsino, stand out as natural candidates for dark matter in the universe. In this paper, we study the search for WIMPs at future multi-TeV μ + μ + colliders.
Hajime Fukuda, Takeo Moroi, Atsuya Niki, Shang-Fu Wei   +3 more
doaj   +1 more source

Reinforcement learning in densely recurrent biological networks

iScience
Summary: Training highly recurrent networks is a technical challenge: gradient-based methods suffer from exploding or vanishing gradients, while purely evolutionary searches converge slowly.
Miles Walter Churchland, Jordi Garcia-Ojalvo   +1 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source