Results 61 to 70 of about 1,348,172 (305)
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Effective Education Methods to Improve Glycemic Control in Type 2 Diabetes Mellitus Patients: A Systematic Review [PDF]
Journal of Preventive Medicine and Public HealthObjectives Education for patients with type 2 diabetes mellitus (T2DM) is essential for reinforcing adherence and engagement to achieve therapeutic objectives, given the chronic nature of the treatment.
Ika Mustikaningtias +3 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FREE SEARCH AND DIFFERENTIAL EVOLUTION TOWARDS DIMENSIONS NUMBER CHANGE [PDF]
, 2006 This paper presents an exploration of Free Search (FS) and modified Differential Evolution (DE) with enhanced adaptivity. The aim of the study is to identify how these methods can cope with changes of the number of variables of a hard design test ...
Penev, Kalin
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Application of pattern search method to power system valve-point economic load dispatch
, 2007 Direct search (DS) methods are evolutionary algorithms used to solve constrained optimization problems. DS methods do not require any information about the gradient of the objective function at hand, while searching for an optimum solution.
AL-Othman, A.K. +2 more
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Application of Pattern Search Method to Power System Economic Load Dispatch
, 2007 Direct Search (DS) methods are evolutionary algorithms used to solve constrained optimization problems. DS methods do not require information about the gradient of the objective function while searching for an optimum solution.
Alsumait, J.S. +2 more
core
Smoothing and worst-case complexity for direct-search methods in nonsmooth optimization [PDF]
, 2013 In the context of the derivative-free optimization of a smooth objective function, it has been shown that the worst-case complexity of direct-search methods is of the same order as that of the steepest descent for derivative-based optimization; more ...
Vicente, Luís Nunes +1 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source