Results 51 to 60 of about 19,887 (300)

Iron Metabolism Genes Shape the Course of Liver Fibrosis in Chronic Hepatitis C: From Disease Progression to Reversal After Direct-Acting Antivirals Treatment. [PDF]

Viruses
Chronic hepatitis C (CHC) is linked to iron overload, which significantly correlates with liver fibrosis. This study aimed to assess whether genetic polymorphisms related to iron metabolism are associated with fibrosis severity, predict improvement in ...
Ferreira J, Bicho M, Faustino P, Serejo F.   +3 more
europepmc   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Direct-acting antivirals lower mortality and recurrence in HCV-related hepatocellular carcinoma post liver resection : A multicenter international study [PDF]

Background: The impact of treatment on hepatitis C virus with direct-acting antivirals on 90-day postoperative outcomes, overall survival, and recurrence-free survival in patients after liver resection for hepatocellular carcinoma is unknown. Methods: We
O'Kane, Grainne M., Patel, Madhukar S., Tadros, Meena, Magyar, Christian T. J., Myers, Bryan, Feld, Jordan J., Magyar, Christian T.J., Fabrega, Joana Ferrer, Ivanics, Tommy, Singal, Amit G., Tabrizian, Parissa, Claasen, Marco, Sapisochin, Gonzalo, Hansen, Bettina, Choi, Woo Jin, Pillai, Anjana, Reig, Maria, Ferrer Fàbrega, Joana, Claasen, Marco; id_orcid, Rocha, Chiara, Li, Zhihao, Parikh, Neehar D., Hunold, Thomas M., Holgin, Victor, Vogel, Arndt   +24 more
core   +2 more sources

Impact of Direct-Acting Antivirals on the Burden of HCV Infection Among Persons Who Inject Drugs and Men Who Have Sex With Men in the Swiss HIV Cohort Study [PDF]

, 2018
In the Swiss HIV Cohort Study, the number of people who inject drugs with replicating hepatitis C virus (HCV) infection decreased substantially after the introduction of direct-acting antivirals (DAAs).
Swiss HIV Cohort Study, Fehr, Jan, Hoffmann, Matthias, Salazar-Vizcaya, Luisa, Rauch, Andri, Wandeler, Gilles, Rougemont, Mathieu, Béguelin, Charles, Braun, Dominique, Béguelin, Charles; https://orcid.org/, Stoeckle, Marcel, Cavassini, Matthias, Bernasconi, Enos   +12 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Unmet needs of chronic hepatitis C in the era of direct-acting antiviral therapy [PDF]

Clinical and Molecular Hepatology, 2020
The treatment of chronic hepatitis C (CHC) has been revolutionized in an era of all-oral direct-acting antivirals (DAAs) since 2014. Satisfactory treatment efficacy and tolerability can be provided by novel DAAs.
Chung-Feng Huang, Ming-Lung Yu
doaj   +1 more source

Direct-Acting Antiviral Agents and the Path to Interferon Independence [PDF]

Clinical Gastroenterology and Hepatology, 2014
Chronic infection with hepatitis C virus (HCV) is a major global health problem; there are approximately 120 to 130 million chronic infections worldwide. Since the discovery of HCV 24 years ago, there has been a relentless effort to develop successful antiviral therapies.
Warren N, Schmidt, David R, Nelson, Jean-Michel, Pawlotsky, Kenneth E, Sherman, David L, Thomas, Raymond T, Chung   +5 more
openaire   +2 more sources

The majority of hepatitis C patients treated with direct acting antivirals are at risk for relevant drug-drug interactions

, 2017
BACKGROUND: Direct-acting antivirals have improved treatment of chronic hepatitis C virus infection significantly. Direct-acting antivirals inhibit/induce and can also be substrates of drug-metabolising enzymes and transporters.
Burger, D.M., Smolders, E.J., Berden, F.A.C., Drenth, J.P.H., Kanter, C.T., Kievit, W.   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source