Results 161 to 170 of about 3,271,959 (246)

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Deprotonation and Alkylation of Weakly Acidic C(sp3)─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert‐Butoxide

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
The use of 1,1,3,3‐tetramethyldisiloxane (TMDSO) and potassium tert‐butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studies support the formation of a substrate‐associated hydride‐like base, providing a single‐step alternative to the classical deprotonation and electrophile ...
Piers St. Onge, Brandon White, Han Yao, Travis Dudding, Stephen G. Newman   +4 more
wiley   +2 more sources

Ambient direct arylation synthesis of thienothiophene based copolymers with mixed alkoxy and oligoether side chains. [PDF]

Chem Sci
Zhu D, Pons I Tarrés J, Kimpel J, Jha M, Craighero M, Asatryan J, Peinador Veiga A, Liu Z, Hidalgo TC, Westwood MM, Fahlman M, Martín J, Giovannitti A, Müller C.   +13 more
europepmc   +1 more source

Nickel catalysis enables convergent paired electrolysis for direct arylation of benzylic C-H bonds. [PDF]

Chem Sci, 2020
Zhang L, Hu X.
europepmc   +1 more source

Photosensitizing Au(I) Catalysis With Coumarins

Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
A Au(I) complex with a tethered coumarin fragment was synthesized and characterized by UV‐vis and emission spectroscopy. Its ability to facilitate photo‐driven cross‐coupling reactions through single‐electron and energy transfer events was evaluated. ABSTRACT Gold catalysis shows versatility in a wide range of challenging transformations, wherein light‐
Liliana Capulín Flores, Jacob J. van der Wal, Johannes E. M. N. Klein   +2 more
wiley   +1 more source

Electrocatalytic Polarity Inversion of Azlactones: Access to α‐Quaternary Amino Acids with Electron‐Rich SOMOphiles

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Electrocatalytic polarity inversion of azlactones unlocks their coupling with electron‐rich reaction partners. Triarylamine‐mediated oxidation of the azlactone enolate generates an electrophilic radical intermediate that undergoes selective C4 functionalization with diverse SOMOphiles.
Paula Rodríguez, David Buedo, Alberto Vega‐Peñaloza, Kian Gosling, Stuart C. D. Kennington, Bart Limburg, Xavier Companyó   +6 more
wiley   +2 more sources

Direct arylation polymerization of electron-rich arenes with polar-group tolerance enabled by ligand-coordination tuning. [PDF]

Chem Sci
Pei X, Wu W, Sun Y, Yang Q, Weng J, Zhang S, Geng Z, Zhu B.   +7 more
europepmc   +1 more source

Synthesis and Characterization of a 2,3-Dialkoxynaphthalene-Based Conjugated Copolymer via Direct Arylation Polymerization (DAP) for Organic Electronics. [PDF]

Polymers (Basel), 2020
Jessop IA, Chong A, Graffo L, Camarada MB, Espinoza C, Angel FA, Saldías C, Tundidor-Camba A, Terraza CA.   +8 more
europepmc   +1 more source

Synthesis of S‐Arylthioxanthonium Trifluoromethanesulfonates From Thioxanthones and Diaryliodonium Salts by Copper(II) Catalysis and Application to Aryl–Heteroaryl Bond Formation by Direct LED Irradiation

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
A straightforward Cu(II)‐catalyzed synthesis of S‐arylthioxanthonium trifluoromethanesulfonates from readily available thioxanthones and diaryliodonium salts is described. A broad range of salts is obtained in moderate to good yields. It is further demonstrated that S‐arylthioxanthonium trifluoromethanesulfonates act as aryl radical precursors under ...
Pierre Boulay, Fabrice Morlet‐Savary, Jean‐Michel Becht   +2 more
wiley   +1 more source

Triazolopyridines. Part 29. Direct arylation reactions with [1,2,3]triazolo[1,5-a]pyridines

ARKIVOC, 2012
Belen Abarca, Rosa Adam, Rafael Ballesteros, Leonardo Chiassai, Cristina Gamón   +4 more
doaj   +1 more source