Results 71 to 80 of about 668,758 (268)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Determinants of healthcare utilization and costs in COPD patients: first longitudinal results from the German COPD cohort COSYCONET

International Journal of COPD, 2019
Danalyn Byng,*,1,2 Johanna I Lutter*,1, Margarethe E Wacker,1 Rudolf A Jörres,3 Xiaofei Liu,4 Stefan Karrasch3,5, Holger Schulz,5 Claus Vogelmeier,6 Rolf Holle1, On behalf of the COSYCONET Consortium1Institute of Health Economics and Health Care ...
Byng D, Lutter JI, Wacker ME, Jörres RA, Liu X, Karrasch S, Schulz H, Vogelmeier C, Holle R   +8 more
doaj  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Pharmacoeconomic Analysis of the Use of Hepatoprotectors in Management of Drug-Associated Liver Injury Due to Hodgkin's Lymphoma Chemotherapy

Антибиотики и Химиотерапия, 2020
The data on the pharmacoeconomic research of the use of Remaxol in treatment of drug-associated liver injury due to the chemotherapy in cancer patients are presented.
D. D. Morikov, E. G. Morikova, V. V. Dvornichenko   +2 more
doaj  

HYPOTHETICAL STUDY ON CALCULATION OF COSTS BY THE METHOD OF CALCULATION BY PHASES [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2019
The paper presents a hypothetical study on the calculation of costs by the method of calculation by phases and the way of organizing the management accounting in relation to the financial accounting of an economic entity having mass production; this ...
BUȘAN GABRIELA, CHIRTOC IRINA-ELENA
doaj  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Calculation of the Full Cost of Education for Students in Various Disciplines at the AJA Command and Staff University (Activity-Based Costing Approach) [PDF]

علوم و فنون نظامی
Objective: This research aims to calculate the full cost of education for students in various disciplines at the AJA Command and Staff University across its four faculties, using the activity-based costing (ABC) approach.Methodology: To calculate the ...
ساسان خادمی, Ali Heydari Shahna, Mir-Hossein Mousavi   +2 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Cost of opioid medication abuse with and without tampering in the USA

ClinicoEconomics and Outcomes Research, 2018
Jeffrey Vietri,1 Elizabeth T Masters,2 Alexandra I Barsdorf,2 Jack Mardekian3 1Health Outcomes Practice, Kantar Health, Horsham, PA, USA; 2Health Economics & Outcomes Research, Pfizer Inc., New York, NY, USA; 3Statistical Research & Data Science ...
Vietri J, Masters ET, Barsdorf AI, Mardekian J   +3 more
doaj  

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source