Results 91 to 100 of about 3,248,511 (314)

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

Exports, Foreign Direct Investment and the Costs of Corporate Taxation [PDF]

open access: yes
This paper develops a model of a monopolistically competitive industry with extensive and intensive business investment and shows how these margins respond to changes in average and marginal corporate tax rates. Intensive investment refers to the size of
Christian Keuschnigg
core   +3 more sources

Cost-effectiveness of scan-directed parathyroidectomy

open access: yesLangenbeck's Archives of Surgery, 2008
Concordant parathyroid localization with sestamibi and ultrasound scans allows minimally invasive parathyroidectomy (MIP) to be performed in patients with non-familial primary hyperparathyroidism (PHPT).To investigate the financial implications of scan-directed parathyroid surgery.Analysis of hospital records for a cohort of consecutive unselected ...
Mihai, R   +4 more
openaire   +2 more sources

What are the factors of the gap between desired and actual fertility? - A comparative study of four developed countries [PDF]

open access: yes
This study is an analysis of the gap between the desired and actual number of children for four developed countries. Although the direct costs of raising children is an indispensable element in decision-making regarding having children, it has hardly ...
Tomo Nishimura
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Determinants of healthcare utilization and costs in COPD patients: first longitudinal results from the German COPD cohort COSYCONET

open access: yesInternational Journal of COPD, 2019
Danalyn Byng,*,1,2 Johanna I Lutter*,1, Margarethe E Wacker,1 Rudolf A Jörres,3 Xiaofei Liu,4 Stefan Karrasch3,5, Holger Schulz,5 Claus Vogelmeier,6 Rolf Holle1, On behalf of the COSYCONET Consortium1Institute of Health Economics and Health Care ...
Byng D   +8 more
doaj  

HYPOTHETICAL STUDY ON CALCULATION OF COSTS BY THE METHOD OF CALCULATION BY PHASES [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2019
The paper presents a hypothetical study on the calculation of costs by the method of calculation by phases and the way of organizing the management accounting in relation to the financial accounting of an economic entity having mass production; this ...
BUȘAN GABRIELA, CHIRTOC IRINA-ELENA
doaj  

The Role of Economic Analysis in Shaping Environmental Policy [PDF]

open access: yes, 1991
The experience of the US in using economic analysis to develop environmental policy is examined. Regulatory actions needed to create environmental benefits often impose substantial costs--both direct costs and indirect effects on other social goals--so ...
Fraas, Arthur
core   +1 more source

EU enlargement, the CAP and the cost of direct payments: a note [PDF]

open access: yes, 2007
Negotiations over EU enlargement have highlighted difficulties in extending the CAP – and in particular direct payments - to the applicant countries, given the spending limits agreed in Berlin in 1999. This note presents estimates of direct payment costs
Ackrill, RW
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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