Results 151 to 160 of about 1,605,931 (317)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
A Leishmania infantum FML-ELISA for the Detection of Symptomatic and Asymptomatic Canine Visceral Leishmaniasis in an Endemic Area of Iran [PDF]
Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum in Mediterranean basin and is an endemic disease in some parts of Iran. Canines are the main reservoirs of VL in most of the endemic areas.
زارعی, ذبیح اله +6 more
core
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
, 2009 Simultaneous detection and identification of multiple pathogenic microorganisms in complex environmental samples are required in numerous diagnostic fields.
Dullemans, A.M. +10 more
core +1 more source
Trends and enabling technologies on high-speed metro and short-reach optical transmission systems
Dianxin kexue, 2019 The optical fiber communication network is the important infrastructure for the modern information society.Thanks to the reduction of fiber loss,the improvement of transceiver devices by electro-optical-electrical conversion,the development of modulation
Lei ZHANG +3 more
doaj
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Bayesian neural network learning for repeat purchase modelling in direct marketing. [PDF]
We focus on purchase incidence modelling for a European direct mail company. Response models based on statistical and neural network techniques are contrasted.
Van den Poel, D +4 more
core
Application of the Fisher-Rao metric to ellipse detection
, 2007 The parameter space for the ellipses in a two dimensional image is a five dimensional manifold, where each point of the manifold corresponds to an ellipse in the image. The parameter space becomes a Riemannian manifold under a Fisher-Rao metric, which is
Stephen J. Maybank, Maybank, Stephen J.
core +1 more source
PhotonicsDirect detection (DD) is a straightforward, cost-effective receiving scheme for medium- and short-range fiber-optic communication systems, yet directly accessing phase information presents inherent challenges. The temporal transport-of-intensity equation
Yue Liu +4 more
doaj +1 more source