Results 151 to 160 of about 3,454,909 (295)

Optical Triple-Band Multiplexing Enabling Beyond-600 Gb/s Single-Photodiode Reception for Intra-AIDC Interconnects

Photonics
Generative artificial intelligence (AI) models including GPT, Gemini, and DeepSeek are reshaping embodied agents, temporal prediction, and autonomous driving, demanding a ten-fold annual growth in training FLOPS that Moore’s law can no longer sustain ...
Ziheng Zhang, Yixiao Zhu, Xiang Cai, Xiansong Fang, Chenbo Zhang, Yimin Hu, Lingjun Zhou, Chongyu Wang, Fan Zhang, Weisheng Hu   +9 more
doaj   +1 more source

Advances in direct optical detection [PDF]

Analytical and Bioanalytical Chemistry, 2020
Baeumner, Antje J., Gauglitz, Guenter, Homola, Jiří   +2 more
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Single photodiode-based direct detection for Twin-SSB-QPSK signal in optical fiber communication systems

Tongxin xuebao
To address the high-cost issue of twin single sideband quadrature phase shift keying (Twin-SSB-QPSK) signals in optical transmission, a optical fiber communication system was proposed, in which a single photodetector (PD) was employed at the receiver to ...
ZHANG Hongbo, LIU Jiao, LING Weiwei, ZHANG Min, WAN Feng, CAI Ju   +5 more
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Advancing poliovirus eradication: lessons learned from piloting direct molecular detection of polioviruses in high-risk and priority geographies

Microbiology Spectrum
In the Global Polio Laboratory Network (GPLN), poliovirus (PV) screening results from acute flaccid paralysis (AFP) surveillance is based on virus isolation (VI) through cell culture, entailing long turnaround times and the amplification of live ...
Paula L. Marcet, Brandon Short, Ashley Deas, Hong Sun, Chelsea Harrington, Shahzad Shaukat, Muhammad Masroor Alam, Marycelin Baba, Adedayo Faneye, Prossy Namuwulya, Lea Necitas Apostol, Tamer Elshaarawy, John Kofi Odoom, Peter Borus, Shelina Moonsamy, Yogolelo Riziki, Marie Claire Endegue Zanga, Mesfin Tefera, Anfumbom K. W. Kfutwah, Salmaan Sharif, Varja Grabovac, Cara C. Burns, Nancy Gerloff   +22 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Direct Detection: Liquid Nobles

Journal of Physics: Conference Series, 2016
Over the past decade, detectors based on liquid noble elements have been at the frontier in the search for WIMP dark matter. They have been shown to powerfully combine low threshold, low background, recoil ID, large mass and self shielding, leading to unprecedented sensitivity to WIMP-nuclear recoil scatters.
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Challenges for the Directional Dark Matter Direct Detection

Journal of Advanced Instrumentation in Science
12 pages, 7 figures, accepted for Journal of Advanced Instrumentation in ...
openaire   +2 more sources