Results 211 to 220 of about 1,526,554 (267)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ONE-GO: Direct detection of context-dependent GPCR activity. [PDF]

Cell Res
Raskovalov A, Kim D, Cherezov V.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Practical Pearls for Direct Detection of Live Treponema pallidum in Primary Syphilis Using a Phase-Contrast Microscope and USB Camera System: A Video-Based Technical Report. [PDF]

Cureus
Ono Y, Miyazawa Y, Arai S, Sekine Y.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Direct Detection and Quantification of Aqueous Proteins via a Fluorescent Probe Through the Use of Fluorophore-Induced Plasmonic Current. [PDF]

Biosensors (Basel)
Pierce DR, Geddes CD.
europepmc   +1 more source

Direct detection of stringent alarmones (pp)pGpp using malachite green. [PDF]

Microb Cell
Schicketanz M, Petrová M, Rejman D, Sosio M, Donadio S, Zhang YE.   +5 more
europepmc   +1 more source

A Strategy Potentially Suitable for Combined Preimplantation Genetic Testing of Aneuploidy and Monogenic Disease That Permits Direct Detection of Pathogenic Variants Including Repeat Expansions and Gene Deletions. [PDF]

Int J Mol Sci
Tan VJ, Liang Y, Tan AS, Wong S, Asherah N, Chua P, Lee CG, Choolani MA, Dang T, Chong SS.   +9 more
europepmc   +1 more source

Direct detection of the chloride release and uptake reactions of Natronomonas pharaonis halorhodopsin. [PDF]

J Biol Chem
Hamada C, Murabe K, Tsukamoto T, Kikukawa T.   +3 more
europepmc   +1 more source