Results 41 to 50 of about 1,136,956 (309)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Functional and Structural Magnetic Resonance Imaging of Humans and Macaques [PDF]

, 2004
Magnetic resonance imaging (MRI) is a technique which finds use in the neurosciences both as an anatomical and functional localization tool. The traditional uses of MRI for structural analysis, such as are commonly found in medicine, can be adapted to ...
Bernheim, Kyle Alan
core   +1 more source

High performance coronagraphy for direct imaging of exoplanets

EPJ Web of Conferences, 2011
Coronagraphy has recently been an extremely active field of research, with several high performance concepts proposed, and several new coronagraphs tested in laboratories and telescopes. Coronagraph concepts can be grouped in a few broad categories: Lyot-
Guyon O.
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Time-resolved quantitative assays and imaging of enzymes and enzyme substrates using a new europium fluorescent probe for hydrogen peroxide

, 2005
The thesis describes the development of a novel reversible H2O2 fluorescent probe comprising the ternary complex of europium(III), tetracycline and hydrogen peroxide; and its application in the assays of H2O2, of H2O2 producing oxidases and their ...
Wu, Meng
core   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

The DAMASK trial protocol: a pragmatic randomised trial to evaluate whether GPs should have direct access to MRI for patients with suspected internal derangement of the knee [PDF]

, 2006
Background: Though new technologies like Magnetic Resonance Imaging (MRI) may be accurate, they often diffuse into practice before thorough assessment of their value in diagnosis and management, and of their effects on patient outcome and costs.
Brealey, Stephen, Stephen D Brealey, T Russell, Ian, Wadsworth, V, Gillan, MG, Fiona Fylan, Maureen GC Gillan, Helen Cox, Houston, H, Hendry, Maggie, Gillan, Maureen, Maggie Hendry, Christine Atwell, Torgerson David, Orchard, Jo, King, David C., Valerie Wadsworth, Cox Helen, Atwell, Christine, Gillan Maureen GC, Brealey, Stephen D., Robling Michael, Helen Houston, Ian T Russell, Russell, Ian, Fylan, Fiona, Cross, Ben, Robling, M, Gilbert, Fiona, Wilkinson Clare, Andrew Garratt, Clare Wilkinson, Michael Robling, Bryan, Stirling, Jo Orchard, David King, Wilkinson, Clare, Brealey, Stephen D, Cox, Helen, Gillan, Maureen G. C., Gilbert, Fiona J, Coulton, Simon, Bryan, S, Coulton, S, Russell, IT, Orchard Jo, Cox, H, Gilbert, Fiona J., Fylan Fiona, Ben Cross, Wilkinson, C, Garratt, Andrew, Coulton Simon, Cross, B, Wadsworth Valerie, Kerenza Hood, Morton, Veronica, Gillan, Maureen G C, Garratt Andrew, Cross Ben, Houston Helen, Houston, Helen, King David, Gilbert, FJ, David Torgerson, Atwell Christine, Hendry, M, Morton Veronica, Torgerson, David J., Russell Ian T, Wadsworth, Valerie, Fiona J Gilbert, Morton, V, Torgerson, D, King, D, Atwell, C, Torgerson, David, Stirling Bryan, Robling, Michael, Simon Coulton, Brealey, SD, Brealey Stephen D, Hood, K, King, David, Garratt, A, Orchard, J, Fylan, F, Hendry Maggie, Bryan Stirling, Gilbert Fiona J, Hood, Kerenza, Hood Kerenza, Veronica Morton   +92 more
core   +1 more source

Direct imaging of photonic nanojets

Optics Express, 2008
We report the direct experimental observation of photonic nanojets created by single latex microspheres illuminated by a plane wave at a wavelength of 520 nm. Measurements are performed with a fast scanning confocal microscope in detection mode, where the detection pinhole defines a diffraction-limited observation volume that is scanned in three ...
Patrick, Ferrand, Jérôme, Wenger, Alexis, Devilez, Martina, Pianta, Brian, Stout, Nicolas, Bonod, Evgueni, Popov, Hervé, Rigneault   +7 more
openaire   +2 more sources

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source