Results 81 to 90 of about 4,947,056 (252)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hidden in Plain Sight: Searching for Dark Companions to Bright Stars with the Large Binocular Telescope and SHARK-VIS

The Astrophysical Journal
We report the results from a pilot study to search for black holes and other dark companions in binary systems using direct imaging with SHARK-VIS and the iLocater pathfinder “Lili” on the Large Binocular Telescope.
D. M. Rowan, T. A. Thompson, C. S. Kochanek, G. Li Causi, J. Roth, P. Vaccari, F. Pedichini, R. Piazzesi, S. Antoniucci, V. Testa, M. C. Johnson, J. Crass, J. R. Crepp, A. Bechter, E. B. Bechter, B. L. Sands, R. J. Harris, B. J. Fulton   +17 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Video-rate or high-precision: A flexible range imaging camera [PDF]

, 2008
A range imaging camera produces an output similar to a digital photograph, but every pixel in the image contains distance information as well as intensity.
Dorrington, Adrian A., Payne, Andrew D., Conroy, Richard M., Andrew D. Payne, Jongenelen, Adrian P.P., Adrian A. Dorrington, Adrian P. P. Jongenelen, Carnegie, Dale A., Michael J. Cree, John P. Godbaz, Godbaz, John Peter, Dale A. Carnegie, Richard M. Conroy, Cree, Michael J.   +13 more
core   +1 more source

New Orbital Constraints for YSES 1 b and HR 2562 B from High-Precision Astrometry and Planetary Radial Velocities

The Astronomical Journal
We present new VLTI/GRAVITY astrometry and updated orbit fits for the directly imaged companions YSES 1 b and HR 2562 B, substellar objects straddling the planet–brown-dwarf boundary.
Jonathan Roberts, William Thompson, Jason J. Wang, Sarah Blunt, William O. Balmer, Guillaume Bourdarot, Brendan P. Bowler, Gael Chauvin, Frank Eisenhauer, Thomas K. Henning, Jens Kammerer, Flavien Kiefer, Matthew A. Kenworthy, Pierre Kervella, Sylvestre Lacour, A.-M. Lagrange, Eric L. Nielsen, Laurent Pueyo, Emily Rickman, Olli Sipilä, Silvia Spezzano, Tomas Stolker, Alice Zurlo   +22 more
doaj   +1 more source

Direct 3D Mass Spectrometry Imaging Analysis of Environmental Microorganisms

Molecules
Assessing the spatial distribution of microorganisms’ metabolites in growth medium remains a challenge. Here, we present the first use of the newly developed LARAPPI/CI-MSI 3D (laser ablation remote atmospheric pressure photoionization/chemical ...
Justyna Szulc, Tomasz Grzyb, Joanna Nizioł, Sumi Krupa, Wiktoria Szuberla, Tomasz Ruman   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Dataset for Optimal Scheduling of Exoplanet Direct Imaging Single Visit Observations of a Blind Search Survey

, 2020
This data is supplemental material for the exoplanet direct imaging yields of the Wide-Field Infrared Survey Telescope (WFIRST) Coronagraphic Instrument (CGI).
Delacroix, Christian, Garrett, Daniel, Soto, Gabriel, Keithly, Dean R., Savransky, Dmitry   +4 more
core   +1 more source

The Effect of Spectral Resolution on Biosignature Detection via Reflected-light Observations of the Earth through Time

The Astrophysical Journal
NASA’s Habitable Worlds Observatory (HWO) will search for biosignatures on Earth-like exoplanets using reflected light spectroscopy. A critical instrument design parameter is resolving power, which must balance biosignature detectability against exposure
Samantha Gilbert-Janizek, Jacob Lustig-Yaeger, Joshua Krissansen-Totton   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source