Results 81 to 90 of about 12,175,310 (293)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Direct Lift Control of Fighter Aircraft

open access: yes, 2019
Direct lift control for aircraft has been around in the aeronautical industry for decades but is mainly used in commercial aircraft with dedicated direct lift control surfaces. The focus of this thesis is to investigate if direct lift control is feasible for a fighter aircraft, similar to Saab JAS 39 Gripen, without dedicated control surfaces.
Öhrn, Philip, Åstrand, Markus
openaire   +1 more source

Velocity vector control system augmented with direct lift control [PDF]

open access: yes, 1981
A pilot-controlled stability control system that employs direct lift control (spoiler control) with elevator control to control the flight path angle of an aircraft is described.
Tisdale, H. F., Sr., Kelly, W. W.
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

The Lift Project: Feelings Follow Your Focus

open access: yes, 2022
The Lift Project is an evidence-based mental health and wellbeing program that draws together the findings of over 400 studies from the disciplines of Neuroscience, Lifestyle Medicine and Positive Psychology.
Morton, Darren
core   +1 more source

A Comprehensive Analysis and Hardware Implementation of Control Strategies for High Output Voltage DC-DC Boost Power Converter

open access: yesInternational Journal of Computational Intelligence Systems, 2017
Classical DC-DC converters used in high voltage direct current (HVDC) power transmission systems, lack in terms of efficiency, reduced transfer gain and increased cost with sensor (voltage/current) numbers.
Sanjeevikumar Padmanaban   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Active control with dielectric barrier discharge actuators applied to high-lift devices

open access: yes, 2013
An experimental investigation examined the capability of dielectric barrier discharge (DBD) actuators to control a high-lift device system. Aerodynamic tests investigated the potential of utilising the actuator to control the flap side-edge vortex flow ...
Chappell, S.
core   +1 more source

Aerodynamic Aspects of the Longitudinal Motion of a High-Lift Aircraft Configuration with Circulation Control [PDF]

open access: yes, 2013
The aim of sub-project C1 of the Collaborative Research Center/Sonderforschungsbereich 880 (SFB 880) is to investigate numerically the flight mechanical characteristics of an aircraft with circulation controlled high-lift devices from an aerodynamic ...
Keller, Dennis, Rudnik, Ralf
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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