Results 101 to 110 of about 39,163,890 (305)

Approximations of solutions for a class of conditionally well-posed integro-differential equations

Учёные записки Казанского университета: Серия Физико-математические науки
In this article, for a specific class of conditionally well-posed integro-differential equations in a novel pair of weighted Sobolev spaces, an alternative method for constructing approximations (particularly finite-dimensional ones) to the solution of ...
J. R. Agachev, M. Yu. Pershagin
doaj   +1 more source

When a Straight Line Is Not the Most Direct Method: an Evaluation of Straight Line Versus True Distance Metrics for Patients in Rural Settings. [PDF]

J Behav Health Serv Res, 2023
Ludrosky JM, Newhouse A, Hudnall E, Sheree A, Perle JG.   +4 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A direct method for the identification of patterns of care using administrative databases: the case of breast cancer. [PDF]

Eur J Health Econ, 2021
Busco S, Tavilla A, Gigli A, Lopez T, Pierannunzio D, Mallone S, Guzzinati S, Capodaglio G, Giusti F, Angiolini C, Francisci S.   +10 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A Direct Method for RT-PCR Detection of SARS-CoV-2 in Clinical Samples. [PDF]

Healthcare (Basel), 2021
El-Kafrawy SA, El-Daly MM, Hassan AM, Kaki RM, Abuzenadah AM, Kamal MA, Azhar EI.   +6 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Methodology for Lost Gas Determination from Exploratory Coal Cores and Comparative Evaluation of the Accuracy of the Direct Method. [PDF]

ACS Omega, 2021
Xu H, Ahmad F, Hu B, Sun G, Liu H, Ding H, Zhang M, Zhang M, Fang H.   +8 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source