Direct numerical simulation of a stationary spherical particle in fluctuating inflows
AIP Advances, 2022 Fully resolved direct numerical simulations are conducted to study the effects of fluctuating freestream flow on the drag force and wake characteristics of a stationary spherical particle.
Yuqi Wang +3 more
doaj +1 more source
Direct numerical simulation of confined weak round fountains in homogeneous ambient
Case Studies in Thermal Engineering, 2021 Fountains (negatively buoyant jets) are commonly used in numerous engineering applications, such as the natural ventilation in buildings and the smoke spread in compartment fires.
Liqiang Dong +2 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
OpenACC Acceleration of Parallel Direct Numerical Simulation of Turbulent Flows [PDF]
Journal of Applied and Computational MechanicsThis work presents a state-of-the-art computational approach for performing large-scale simulations of turbulence on heterogeneous compute nodes.
Ahmed Abdellatif +3 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Laminar–Turbulent Intermittency in Annular Couette–Poiseuille Flow: Whether a Puff Splits or Not
Entropy, 2020 Direct numerical simulations were carried out with an emphasis on the intermittency and localized turbulence structure occurring within the subcritical transitional regime of a concentric annular Couette–Poiseuille flow.
Hirotaka Morimatsu, Takahiro Tsukahara
doaj +1 more source
In-service weld repair by direct deposition: Numerical simulation and experimental validation
Engineering Science and Technology, an International Journal, 2023 In-Service Welding is a technological process for which interconnection and repair of pipelines can be made while they are in operation, before making it two main risks need to be assessed: hydrogen cracking and burn-through.
Luis Dante Meléndez-Morales +2 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Direct Pore‐Scale Numerical Simulation of Microbially Induced Calcium Carbonate Precipitation
Water Resources Research, 2023 Microbially induced calcium carbonate precipitation (MICP) is a promising method for eco‐friendly solutions in geotechincal engineering. MICP involves highly coupled processes in geochemistry and bacterial metabolism that take place in a porous medium ...
Mohammad Amin Razbani +2 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source