Results 41 to 50 of about 7,328,723 (240)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Comparison of Subgrid-scale Viscosity Models and Selective Filtering Strategy for Large-eddy Simulations [PDF]
, 2013 Explicitly filtered large-eddy simulations (LES), combining high-accuracy schemes with the use of a selective filtering without adding an explicit subgrid-scales (SGS) model, are carried out for the Taylor-Green-vortex and the supersonic-boundary-layer ...
STEFANIN VOLPIANI, Pedro +3 more
core +1 more source
Direct numerical simulation of confined weak round fountains in homogeneous ambient
Case Studies in Thermal Engineering, 2021 Fountains (negatively buoyant jets) are commonly used in numerous engineering applications, such as the natural ventilation in buildings and the smoke spread in compartment fires.
Liqiang Dong +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Laminar–Turbulent Intermittency in Annular Couette–Poiseuille Flow: Whether a Puff Splits or Not
Entropy, 2020 Direct numerical simulations were carried out with an emphasis on the intermittency and localized turbulence structure occurring within the subcritical transitional regime of a concentric annular Couette–Poiseuille flow.
Hirotaka Morimatsu, Takahiro Tsukahara
doaj +1 more source
Numerical simulation of direct shear test of sand considering rotational impedance
Shuili Shuiyun Gongcheng Xuebao, 2021 A series of sand direct shear numerical simulation tests were performed using the discrete element method, so as to investigate the inherent relation of meso-mechanics between the particle’s rotation-resistant capacity and the interaction of sands and ...
WANG Zhuang +3 more
doaj +1 more source
Direct numerical simulation of noninvasive channel healing in electrical field
Advances in Mechanical Engineering, 2017 Noninvasive channel healing is a new idea to repair the broken pipe wall, using external electric fields to drive iron particles to the destination. The repair can be done in the normal operation of the pipe flow without any shutdown of the pipeline so ...
Yi Wang, Shuyu Sun
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
A primer on direct numerical simulation of turbulence - methods, procedures and guidelines
, 2010 Direct Numerical Simulation (DNS) is the branch of CFD devoted to high-fidelity solution ofturbulent flows. DNS differs from conventional CFD in that the turbulence is explicitly resolved,rather than modelled by a Reynolds-averaged Navier-Stokes (RANS ...
Sandberg, Richard D., Coleman, Gary N.
core +1 more source