Results 61 to 70 of about 7,328,723 (240)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Near-Field Aeroacoustics of Spanwise Forcing on a Transonic Wing: A DNS Study
Applied SciencesThe transonic airflow around a supercritical wing with a shock wave is described via direct numerical simulations. Flow control for turbulent drag reduction is applied via streamwise traveling waves of spanwise velocity applied on a finite portion of the
Niccolò Berizzi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Experimentation and direct numerical simulation of self-similar convergent detonation wave
EPJ Web of Conferences, 2011 The propagation of self similar convergent detonation wave in TATB-based explosive composition was studied both experimentally and numerically. The device constists in a 50 mm cylinder of TATB surrounded by an HMX tube.
Bozier O., Matignon C., Sorin R.
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Direct Numerical Simulation of Compressible Turbulent Flows
, 2010 This paper reviews the authors' recent studies on compressible turbulence by using direct numerical simulation (DNS), including DNS of isotropic (decaying) turbulence, turbulent mixing-layer, turbulent boundary-layer and shock/boundary-layer interaction.
马延文 +4 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Low Reynolds Number Flow Around Tori of Different Slenderness Γ
Applied Sciences, 2017 We present the results of axisymmetric and three-dimensional numerical simulations of the flow around a torus in the low Reynolds number regime [ 10 − 2 ; 3 × 10 3 ] and aspect-ratio 0 < Γ = 2 a / R ≤ 2 (core diameter ...
Werner M. J. Lazeroms +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source