Results 81 to 90 of about 7,328,723 (240)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Direct numerical simulation of turbulent flow past a trailing edge and the associated noise generation

, 2008
Direct numerical simulations (DNS) are conducted of turbulent flow passing an infinitely thin trailing edge (TE). The objective is to investigate the turbulent flow field in the vicinity of the TE and the associated broadband noise generation.
Sandberg, Richard D., Sandham, Neil D.
core   +1 more source

Numerical Simulation of Direct and Inverse Problems of Pollutant Diffusion Using Advanced Numerical Methods

Mathematics
This paper investigates numerical modeling of transport and diffusion processes of harmful impurities governed by the advection–diffusion–reaction equation, along with the solution of corresponding direct and inverse problems.
Dinara Tamabay, Marzhan Temirbekova, Ainur Kabulova, Shadiyar Altynbekov, Nauryzbay Adil, Syrym Kasenov   +5 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Direct numerical simulation of heat transfer from the stagnation region of a heated cylinder affected by an impinging wake [PDF]

, 2011
Copyright © 2011 Cambridge University Press.The effect of an incoming wake on the flow around and heat transfer from the stagnation region of a circular cylinder was studied using direct numerical simulations (DNSs).
Rodi, W, JAN G. WISSINK, WOLFGANG RODI, Wissink, JG   +3 more
core   +1 more source

Direct Numerical Simulation of Solute Transport in Bioclogged Porous Media

Water Resources Research
Biofilms in porous media significantly impact solute transport, beyond their role in reducing permeability through bioclogging. Experimental evidence has shown that biofilms can induce anomalous transport behaviors such as increased dispersion and ...
Malik A. Dawi, Michele Starnoni, Martina Siena, Giovanni Porta, Xavier Sanchez‐Vila   +4 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Numerical simulation of drying of Pinus pseudostrobus wood with Comsol Multiphysics [PDF]

, 2011
In this work, we present the second part of our investigation. In the first part, we have published a semi-empirical model for drying. In this second part, we present the numerical solution of a drying model for Pinus pseudostrobus (Mexican softwood ...
HERNANDEZ-BAUTISTA, Emilio, SANDOVAL-TORRES, Sadoth, Hernández-Bautista, E., Rodríguez-Ramírez, J., Nadeou, J. P., MÉNDEZ-LAGUNAS, Lilia Leticia, NADEAU, Jean-Pierre, HERNANDEZ-BAUTISTA, , E, RODRÍGUEZ-RAMÍREZ, Juan, Méndez-Lagunas, L., SANDOVAL-TORRES, S., RODRÍGUEZ-RAMÍREZ, , J.   +11 more
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source