Results 71 to 80 of about 121,753 (310)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Bottleneck in the Scalar Dissipation Rate Spectra: Dependence on the Schmidt Number

Fluids
The mean dissipation rate of turbulent energy reaches a constant value at high Taylor–Reynolds numbers (Rλ). This value is associated with the well-scaling dissipation spectrum in Kolmogorov units, where the maximum corresponds to the bottleneck peak ...
Paolo Orlandi
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Lattice Boltzmann method for direct numerical simulation of turbulent flows [PDF]

, 2010
We present three-dimensional numerical simulations (DNS) of the Kida vortex flow, a prototypical turbulent flow, using a novel high-order lattice Boltzmann model.
A. G. TOMBOULIDES, S. S. CHIKATAMARLA, Tomboulides, A.G., Boulouchos, Konstantinos, K. B. BOULOUCHOS, Frouzakis, C.E., Boulouchos, K.B., C. E. FROUZAKIS, I. V. KARLIN, Karlin, Ilya, Chikatamarla, S.S., Karlin, I.V.   +11 more
core   +1 more source

Experimentation and direct numerical simulation of self-similar convergent detonation wave

EPJ Web of Conferences, 2011
The propagation of self similar convergent detonation wave in TATB-based explosive composition was studied both experimentally and numerically. The device constists in a 50 mm cylinder of TATB surrounded by an HMX tube.
Bozier O., Matignon C., Sorin R.
doaj   +1 more source

Low Reynolds Number Flow Around Tori of Different Slenderness Γ

Applied Sciences, 2017
We present the results of axisymmetric and three-dimensional numerical simulations of the flow around a torus in the low Reynolds number regime [ 10 − 2 ; 3 × 10 3 ] and aspect-ratio 0 < Γ = 2 a / R ≤ 2 (core diameter ...
Werner M. J. Lazeroms, Marco D. de Tullio, Nicola De Santis, Roberto Pizzoferrato, Roberto Verzicco   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Direct numerical simulation of turbulent Taylor–Couette flow [PDF]

European Journal of Mechanics - B/Fluids, 2008
To appear in European Journal of Mechanics B ...
PIRRO', DAVIDE, QUADRIO, MAURIZIO
openaire   +4 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source