Results 41 to 50 of about 95,386 (312)

Turbulent Channel Flow: Direct Numerical Simulation-Data-Driven Modeling

open access: yesFluids
Data obtained using direct numerical simulations (DNS) of pressure-driven turbulent channel flow are studied in the range 180 ≤Reτ≤ 10,000. Reynolds number effects on the mean velocity profile (MVP) and second order statistics are analyzed with a view of
Antonios Liakopoulos, Apostolos Palasis
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Direct Numerical Simulation of Laminar-Turbulent Transition on Grids with Local Refinement

open access: yesУчёные записки Казанского университета: Серия Физико-математические науки, 2017
This paper considers a method of building composite grids with local refinement for direct numerical simulation of flows in a channel with transverse cylindrical rib at moderate Reynolds numbers.
D.I. Okhotnikov
doaj  

Direct numerical simulation of noninvasive channel healing in electrical field

open access: yesAdvances in Mechanical Engineering, 2017
Noninvasive channel healing is a new idea to repair the broken pipe wall, using external electric fields to drive iron particles to the destination. The repair can be done in the normal operation of the pipe flow without any shutdown of the pipeline so ...
Yi Wang, Shuyu Sun
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Numerical Simulation Study on the Effects of Course Keeping on the Roll Stability of Submarine Emergency Rising

open access: yesApplied Sciences, 2019
A direct numerical simulation method based on Reynolds Average Navier−Stokes (RANS) equations is used to carry out numerical prediction studies of submarine emergency rising in this paper.
Shudi Zhang   +4 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Direct Two–Phase Numerical Simulation of Snowdrift Remediation using Three–Dimensional Deflection Fins

open access: yesJournal of Applied Fluid Mechanics, 2012
We present a versatile three – dimensional two – phase model for simulating snow drift relocation around buildings utilizing deflection fins of various shapes and sizes.
E Maldonado, M.W. Roth
doaj  

The Bottleneck in the Scalar Dissipation Rate Spectra: Dependence on the Schmidt Number

open access: yesFluids
The mean dissipation rate of turbulent energy reaches a constant value at high Taylor–Reynolds numbers (Rλ). This value is associated with the well-scaling dissipation spectrum in Kolmogorov units, where the maximum corresponds to the bottleneck peak ...
Paolo Orlandi
doaj   +1 more source

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