Results 221 to 230 of about 41,304 (260)
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Direct Oral Anticoagulants in Cirrhosis
Current Treatment Options in Gastroenterology, 2016The risk of thrombosis in patients with chronic liver disease is increasingly recognized. As patients with cirrhosis develop indications for anticoagulation therapy (e.g., venous thromboembolism, portal vein thrombosis, or atrial fibrillation), providers are left to make difficult decisions when selecting therapeutics with little evidence to rely on ...
Nicolas M, Intagliata +2 more
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DeckerMed Critical Care of the Surgical Patient, 2017
Non–vitamin K antagonist oral anticoagulants, also known as direct oral anticoagulants, are a relatively recent class of medications introduced into clinical practice. Due to their safety profiles, fixed dosing, and lack of need for frequent laboratory monitoring, they are becoming preferred to traditional anticoagulation with warfarin in many cases of
Michael G Mount, Panna A. Codner
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Non–vitamin K antagonist oral anticoagulants, also known as direct oral anticoagulants, are a relatively recent class of medications introduced into clinical practice. Due to their safety profiles, fixed dosing, and lack of need for frequent laboratory monitoring, they are becoming preferred to traditional anticoagulation with warfarin in many cases of
Michael G Mount, Panna A. Codner
openaire +2 more sources
Role of Direct Oral Anticoagulants in the Management of Anticoagulation
Southern Medical Journal, 2017For decades, vitamin K antagonists (VKAs) have been the oral treatment of choice for many thromboembolic conditions. The limitations of VKAs include the need for monitoring through blood testing, drug interactions, and narrow therapeutic windows. These shortcomings have led to the development of direct oral anticoagulants.
Rajiv N, Thakkar +2 more
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Measuring Direct Oral Anticoagulants
2017Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates ...
Robert C, Gosselin, Jonathan, Douxfils
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New anticoagulants: Moving beyond the direct oral anticoagulants
Journal of Thrombosis and Haemostasis, 2021Although anticoagulants have been in use for more than 80 years, heparin and vitamin K antagonists were the sole available options until recently. Although these agents revolutionized the prevention and treatment of thrombotic diseases, their use has been hampered by the necessity for coagulation monitoring and by bleeding complications resulting in ...
James C. Fredenburgh, Jeffrey I. Weitz
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Direct oral anticoagulants for use in paediatrics
The Lancet Child & Adolescent Health, 2022With the increasing incidence of thromboembolism in children and improvement in management for patients with medically complex diseases, expanded availability of safe and effective anticoagulant medications is needed. Traditionally, the most common anticoagulants used for the treatment or prevention of venous thromboembolism or embolic stroke in ...
Julie, Jaffray, Guy, Young
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Detection of lupus anticoagulant in the era of direct oral anticoagulants
Autoimmunity Reviews, 2017Lupus anticoagulant (LAC) is an in vitro phenomenon determining a phospholipid-dependent elongation of clotting times. The presence of LAC associated with anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies is strongly associated with thrombosis and pregnancy morbidity.
HOXHA, ARIELA +3 more
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Direct oral anticoagulants in hypercoagulable states
Journal of Thrombosis and Thrombolysis, 2016Direct oral anticoagulants have been shown safe and effective in the treatment of pulmonary emboli and deep vein thrombi. Their role in the treatment of patients with hypercoagulability is uncertain. We designed a retrospective exploratory analysis of all patients with definite heparin induced thrombocytopenia (HIT) and antiphospholipid syndrome (APS ...
Paul R, Kunk +4 more
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[Anticoagulation-direct oral anticoagulants].
Der Internist, 2018Since direct oral anticoagulants (DOAC) have become available, use of anticoagulant treatment has become easier and safer-for patients suffering from thromboembolic diseases as well as for patients with atrial fibrillation: Because of constant bioavailability, fixed dose regimen treatment is possible, monitoring not necessary and severe bleeding ...
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Direct oral anticoagulant medications in calciphylaxis
International Journal of Dermatology, 2017AbstractBackgroundRecent studies suggest that calciphylaxis is a thrombotic condition in which arteriolar thrombosis leads to painful skin infarcts and consequent morbidity and mortality. Paradoxically, warfarin is implicated as a risk factor for calciphylaxis.
Brian J, King +6 more
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