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Measuring Direct Oral Anticoagulants
, 2017 Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates ...
Robert C, Gosselin, Jonathan, Douxfils
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Direct oral anticoagulants: An update
Medicina Clínica (English Edition), 2018Vitamin K antagonists were the only choice for chronic oral anticoagulation for more than half a century. Over the past few years, direct oral anticoagulants have emerged, including one direct thrombin inhibitor (dabigatran etexilate) and three factor Xa inhibitors (apixaban, edoxaban and rivaroxaban).
Ana Isabel, Franco Moreno +2 more
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Edoxaban: A direct oral anticoagulant
American Journal of Health-System Pharmacy, 2017The pharmacology, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, and place in therapy of edoxaban for prevention of stroke in patients with nonvalvular atrial fibrillation (AF) and treatment of venous thromboembolism (VTE) are reviewed.Although warfarin has been an established therapy for stroke prevention in AF and VTE, the need for ...
Mara, Poulakos +3 more
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Direct Oral Anticoagulants in Cirrhosis
Current Treatment Options in Gastroenterology, 2016The risk of thrombosis in patients with chronic liver disease is increasingly recognized. As patients with cirrhosis develop indications for anticoagulation therapy (e.g., venous thromboembolism, portal vein thrombosis, or atrial fibrillation), providers are left to make difficult decisions when selecting therapeutics with little evidence to rely on ...
Nicolas M, Intagliata +2 more
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DeckerMed Critical Care of the Surgical Patient, 2017
Non–vitamin K antagonist oral anticoagulants, also known as direct oral anticoagulants, are a relatively recent class of medications introduced into clinical practice. Due to their safety profiles, fixed dosing, and lack of need for frequent laboratory monitoring, they are becoming preferred to traditional anticoagulation with warfarin in many cases of
Michael G Mount, Panna A. Codner
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Non–vitamin K antagonist oral anticoagulants, also known as direct oral anticoagulants, are a relatively recent class of medications introduced into clinical practice. Due to their safety profiles, fixed dosing, and lack of need for frequent laboratory monitoring, they are becoming preferred to traditional anticoagulation with warfarin in many cases of
Michael G Mount, Panna A. Codner
openaire +2 more sources