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Role of Direct Oral Anticoagulants in the Management of Anticoagulation
Southern Medical Journal, 2017For decades, vitamin K antagonists (VKAs) have been the oral treatment of choice for many thromboembolic conditions. The limitations of VKAs include the need for monitoring through blood testing, drug interactions, and narrow therapeutic windows. These shortcomings have led to the development of direct oral anticoagulants.
Rajiv N, Thakkar +2 more
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New anticoagulants: Moving beyond the direct oral anticoagulants
Journal of Thrombosis and Haemostasis, 2021Although anticoagulants have been in use for more than 80 years, heparin and vitamin K antagonists were the sole available options until recently. Although these agents revolutionized the prevention and treatment of thrombotic diseases, their use has been hampered by the necessity for coagulation monitoring and by bleeding complications resulting in ...
James C. Fredenburgh, Jeffrey I. Weitz
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Direct oral anticoagulants for use in paediatrics
The Lancet Child & Adolescent Health, 2022With the increasing incidence of thromboembolism in children and improvement in management for patients with medically complex diseases, expanded availability of safe and effective anticoagulant medications is needed. Traditionally, the most common anticoagulants used for the treatment or prevention of venous thromboembolism or embolic stroke in ...
Julie, Jaffray, Guy, Young
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Detection of lupus anticoagulant in the era of direct oral anticoagulants
Autoimmunity Reviews, 2017Lupus anticoagulant (LAC) is an in vitro phenomenon determining a phospholipid-dependent elongation of clotting times. The presence of LAC associated with anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies is strongly associated with thrombosis and pregnancy morbidity.
HOXHA, ARIELA +3 more
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Direct oral anticoagulants in hypercoagulable states
Journal of Thrombosis and Thrombolysis, 2016Direct oral anticoagulants have been shown safe and effective in the treatment of pulmonary emboli and deep vein thrombi. Their role in the treatment of patients with hypercoagulability is uncertain. We designed a retrospective exploratory analysis of all patients with definite heparin induced thrombocytopenia (HIT) and antiphospholipid syndrome (APS ...
Paul R, Kunk +4 more
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[Anticoagulation-direct oral anticoagulants].
Der Internist, 2018Since direct oral anticoagulants (DOAC) have become available, use of anticoagulant treatment has become easier and safer-for patients suffering from thromboembolic diseases as well as for patients with atrial fibrillation: Because of constant bioavailability, fixed dose regimen treatment is possible, monitoring not necessary and severe bleeding ...
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Direct oral anticoagulant medications in calciphylaxis
International Journal of Dermatology, 2017AbstractBackgroundRecent studies suggest that calciphylaxis is a thrombotic condition in which arteriolar thrombosis leads to painful skin infarcts and consequent morbidity and mortality. Paradoxically, warfarin is implicated as a risk factor for calciphylaxis.
Brian J, King +6 more
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Direct oral anticoagulants today
Medicina Clínica (English Edition), 2021Carlos, Escobar Cervantes +1 more
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Direct Oral Anticoagulants in Cancer Patients
Seminars in Thrombosis and Hemostasis, 2019AbstractCancer-associated thrombosis (CAT) is a common occurrence in the journey of a cancer patient and its management poses significant challenges. Low molecular weight heparin (LMWH) is the standard of care but the high cost and the inconvenience of daily injections have led to low persistence with therapy.
Deepa, Suryanarayan +2 more
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Changes in the landscape of anticoagulation: a focus on direct oral anticoagulants
The Lancet HaematologyOver the last decade, the advent of direct oral anticoagulants (DOACs) has rapidly changed the landscape of anticoagulation. In the early 2010s, DOACs became widely available for stroke prevention in atrial fibrillation and the treatment of venous thromboembolism.
Ageno W. +4 more
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