Results 261 to 270 of about 4,435,862 (297)
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Role of Direct Oral Anticoagulants in the Management of Anticoagulation
Southern Medical Journal, 2017For decades, vitamin K antagonists (VKAs) have been the oral treatment of choice for many thromboembolic conditions. The limitations of VKAs include the need for monitoring through blood testing, drug interactions, and narrow therapeutic windows. These shortcomings have led to the development of direct oral anticoagulants.
Rajiv N, Thakkar +2 more
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New anticoagulants: Moving beyond the direct oral anticoagulants
Journal of Thrombosis and Haemostasis, 2021Although anticoagulants have been in use for more than 80 years, heparin and vitamin K antagonists were the sole available options until recently. Although these agents revolutionized the prevention and treatment of thrombotic diseases, their use has been hampered by the necessity for coagulation monitoring and by bleeding complications resulting in ...
James C. Fredenburgh, Jeffrey I. Weitz
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ROTEM Testing for Direct Oral Anticoagulants
Seminars in Thrombosis and Hemostasis, 2021AbstractDirect oral anticoagulants (DOACs) are increasingly used worldwide for the prevention of stroke in patients with atrial fibrillation and to prevent or treat venous thromboembolism. In situations such as serious bleeding, the need for urgent surgery/intervention or the management of a thromboembolic event, the laboratory measurement of DOACs ...
Barbora, Korpallová +7 more
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Direct oral anticoagulants for use in paediatrics
The Lancet Child & Adolescent Health, 2022With the increasing incidence of thromboembolism in children and improvement in management for patients with medically complex diseases, expanded availability of safe and effective anticoagulant medications is needed. Traditionally, the most common anticoagulants used for the treatment or prevention of venous thromboembolism or embolic stroke in ...
Julie, Jaffray, Guy, Young
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Detection of lupus anticoagulant in the era of direct oral anticoagulants
Autoimmunity Reviews, 2017Lupus anticoagulant (LAC) is an in vitro phenomenon determining a phospholipid-dependent elongation of clotting times. The presence of LAC associated with anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies is strongly associated with thrombosis and pregnancy morbidity.
HOXHA, ARIELA +3 more
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[Anticoagulation-direct oral anticoagulants].
Der Internist, 2018Since direct oral anticoagulants (DOAC) have become available, use of anticoagulant treatment has become easier and safer-for patients suffering from thromboembolic diseases as well as for patients with atrial fibrillation: Because of constant bioavailability, fixed dose regimen treatment is possible, monitoring not necessary and severe bleeding ...
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The promise of novel direct oral anticoagulants
Best Practice & Research Clinical Haematology, 2012The standard effective treatment of venous and arterial thromboembolism includes unfractionated and low-molecular weight heparin as well as warfarin, which have major disadvantages. In recent years, new anticoagulants have been developed in an attempt to overcome the known limitations of established treatment and develop improved therapies.
Ron, Hoffman, Benjamin, Brenner
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2015
Direct oral anticoagulants (DOACs) are rapidly changing the way we think about selecting, treating, and monitoring patients in need of anticoagulation. These agents may be used for either treatment or prophylaxis of systemic embolism and have been compared to vitamin K antagonist (e.g., warfarin) for many of the same indications.
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Direct oral anticoagulants (DOACs) are rapidly changing the way we think about selecting, treating, and monitoring patients in need of anticoagulation. These agents may be used for either treatment or prophylaxis of systemic embolism and have been compared to vitamin K antagonist (e.g., warfarin) for many of the same indications.
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Direct oral anticoagulant medications in calciphylaxis
International Journal of Dermatology, 2017AbstractBackgroundRecent studies suggest that calciphylaxis is a thrombotic condition in which arteriolar thrombosis leads to painful skin infarcts and consequent morbidity and mortality. Paradoxically, warfarin is implicated as a risk factor for calciphylaxis.
Brian J, King +6 more
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Direct oral anticoagulants today
Medicina Clínica (English Edition), 2021Carlos, Escobar Cervantes +1 more
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