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Direct oral anticoagulants: An update
Medicina Clínica (English Edition), 2018Vitamin K antagonists were the only choice for chronic oral anticoagulation for more than half a century. Over the past few years, direct oral anticoagulants have emerged, including one direct thrombin inhibitor (dabigatran etexilate) and three factor Xa inhibitors (apixaban, edoxaban and rivaroxaban).
Ana Isabel, Franco Moreno +2 more
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Edoxaban: A direct oral anticoagulant
American Journal of Health-System Pharmacy, 2017The pharmacology, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, and place in therapy of edoxaban for prevention of stroke in patients with nonvalvular atrial fibrillation (AF) and treatment of venous thromboembolism (VTE) are reviewed.Although warfarin has been an established therapy for stroke prevention in AF and VTE, the need for ...
Mara, Poulakos +3 more
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Direct Oral Anticoagulants in Cirrhosis
Current Treatment Options in Gastroenterology, 2016The risk of thrombosis in patients with chronic liver disease is increasingly recognized. As patients with cirrhosis develop indications for anticoagulation therapy (e.g., venous thromboembolism, portal vein thrombosis, or atrial fibrillation), providers are left to make difficult decisions when selecting therapeutics with little evidence to rely on ...
Nicolas M, Intagliata +2 more
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Direct oral anticoagulants today
Medicina Clínica (English Edition), 2021Carlos, Escobar Cervantes +1 more
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2015
Direct oral anticoagulants (DOACs) are rapidly changing the way we think about selecting, treating, and monitoring patients in need of anticoagulation. These agents may be used for either treatment or prophylaxis of systemic embolism and have been compared to vitamin K antagonist (e.g., warfarin) for many of the same indications.
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Direct oral anticoagulants (DOACs) are rapidly changing the way we think about selecting, treating, and monitoring patients in need of anticoagulation. These agents may be used for either treatment or prophylaxis of systemic embolism and have been compared to vitamin K antagonist (e.g., warfarin) for many of the same indications.
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Direct Oral Anticoagulation in Cancer Patients
2021Thrombosis is a leading cause of mortality in cancer patients. Cancer patients are at an increased risk of developing atrial fibrillation, and venous thromboembolism is a leading cause of mortality, especially in patients undergoing chemotherapy. The anticoagulant strategy to be administered in these cases is particularly difficult to choose due to an ...
Bottino R. +6 more
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Direct oral anticoagulants in hypercoagulable states
Journal of Thrombosis and Thrombolysis, 2016Direct oral anticoagulants have been shown safe and effective in the treatment of pulmonary emboli and deep vein thrombi. Their role in the treatment of patients with hypercoagulability is uncertain. We designed a retrospective exploratory analysis of all patients with definite heparin induced thrombocytopenia (HIT) and antiphospholipid syndrome (APS ...
Paul R, Kunk +4 more
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[Anticoagulation-direct oral anticoagulants].
Der Internist, 2018Since direct oral anticoagulants (DOAC) have become available, use of anticoagulant treatment has become easier and safer-for patients suffering from thromboembolic diseases as well as for patients with atrial fibrillation: Because of constant bioavailability, fixed dose regimen treatment is possible, monitoring not necessary and severe bleeding ...
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Direct Oral Anticoagulants in Atrial Fibrillation
Seminars in Hematology, 2014Atrial fibrillation (AF), the most frequent sustained arrhythmia, is associated with an increased risk of thromboembolic events. The risk of stroke depends on risk factors such as age, hypertension, heart failure, and vascular disease. Thus, antithrombotic therapy is a cornerstone in the management of AF.
Georg, Noll +2 more
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Direct oral anticoagulant medications in calciphylaxis
International Journal of Dermatology, 2017AbstractBackgroundRecent studies suggest that calciphylaxis is a thrombotic condition in which arteriolar thrombosis leads to painful skin infarcts and consequent morbidity and mortality. Paradoxically, warfarin is implicated as a risk factor for calciphylaxis.
Brian J, King +6 more
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