Results 71 to 80 of about 4,435,862 (297)

Laboratory measurement of the direct oral anticoagulants [PDF]

British Journal of Haematology, 2015
SummaryDirect oral anticoagulants (DOACs), including the direct thrombin inhibitor, dabigatran, and the direct factor Xa (FXa) inhibitors, rivaroxaban, apixaban and edoxaban, are approved for thromboembolism prevention and treatment. These drugs do not require routine coagulation monitoring but, in some circumstances, measurement of drug level or ...
Brian J, Dale, Noel C, Chan, John W, Eikelboom   +2 more
openaire   +2 more sources

Will Direct Oral Anticoagulants Have a Chance in Prosthetic Valves? [PDF]

, 2020
Although there are abundant data highlighting the safety and efficacy of direct oral anticoagulants, to date, recent guidelines have limited their use to stroke prevention in patients with non-valvular AF, as well as in the prevention and treatment of ...
Abdallah Almaghraby, Mahmoud Abdelnabi, Yehia Saleh   +2 more
core   +1 more source

Impact of parameter settings on the estimation of drug exposure with the individualized dispensing patterns method

British Journal of Clinical Pharmacology, EarlyView.
Aim To assess the impact of parameter settings when using the individualized dispensing patterns (IDP) method to estimate exposure duration from dispensing data. Methods We conducted a cohort study using a 2% representative sample of the French healthcare insurance database from 2013 to 2022.
Laëtitia Gosselin, Clara Lévy, Noémie Sève, Thierry Blanchon, Marianne Sarazin, Louise Rossignol, Maryse Lapeyre‐Mestre, Nathanaël Lapidus, Olivier Steichen   +8 more
wiley   +1 more source

Influence of Direct Oral Anticoagulants on Rates of Oral Anticoagulation for Atrial Fibrillation

Journal of the American College of Cardiology, 2017
Oral anticoagulation (OAC) with warfarin is underused for atrial fibrillation (AF). The availability of direct oral anticoagulants (DOACs) may improve overall OAC rates in AF patients, but a large-scale evaluation of their effects has not been conducted.This study assessed the effect of DOAC availability on overall OAC rates for nonvalvular AF.Between ...
Lucas N, Marzec, Jingyan, Wang, Nilay D, Shah, Paul S, Chan, Henry H, Ting, Kensey L, Gosch, Jonathan C, Hsu, Thomas M, Maddox   +7 more
openaire   +2 more sources

Monitoring and reversal of direct oral anticoagulants [PDF]

Hematology, 2015
AbstractAlthough the direct oral anticoagulants (DOACs) do not require routine monitoring and reduce bleeding compared with warfarin, there are special circumstances in which laboratory measurement or reversal of their anticoagulant effect may be indicated.
Adam, Cuker, Deborah, Siegal
openaire   +2 more sources

Mobile health interventions to improve adherence to oral anticoagulant treatment: A systematic review and critical analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Non‐adherence to oral anticoagulants (OACs) is associated with significant morbidity and mortality. Mobile health (mHealth) interventions have been used to improve medication adherence across the three phases of initiation, implementation and persistence.
Non Davies, Elin Haf Davies, Dyfrig A. Hughes   +2 more
wiley   +1 more source

Assessment and predictors of inappropriate dose of direct oral anticoagulants

Italian Journal of Medicine
Direct-Acting Oral Anticoagulants (DOACs) have revolutionized the management of Atrial Fibrillation (AF) and Venous Thromboembolism (VTE). However, recent audits reveal a significant burden of inappropriate dosages in the prescribing of direct-acting ...
Mosaad O. Almegren
doaj   +1 more source

Warfarin time in therapeutic range of primary healthcare patients in the Western Cape Province, South Africa

British Journal of Clinical Pharmacology, EarlyView.
Introduction Warfarin therapy is the mainstay of anticoagulation treatment in South Africa and requires frequent INR monitoring due to interindividual patient variability. Time in therapeutic range (TTR) reflects the proportion of total treatment time during which INR values are within therapeutic range.
Masudah Paleker, Christopher Kelly, Robin Dyers, Eric Decloedt   +3 more
wiley   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Direct Oral Anticoagulants in Cancer Patients

healthbook TIMES. Oncology Hematology
Patients with active cancer have an increased risk of arterial occlusion, venous thromboembolism (VTE) and bleeding events. Traditionally, these patients were treated with low-molecular-weight heparins to reduce the risk of VTE, while vitamin K ...
Nicolas Bonadies, Jan-Dirk Studt, Stefani Parmentier, Dimitrios A. Tsakiris   +3 more
doaj   +1 more source