Results 41 to 50 of about 64,360 (256)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Blind despreading and deconvolution of asynchronous multiuser direct sequence spread spectrum signals under multipath channels

IET Signal Processing, 2023
In non‐cooperative scenarios, the spreading sequences or waveforms of the direct sequence spread spectrum (DSSS) signals is unknown to the receiver.
Liangliang Li, Huaguo Zhang, Songmao Du, Tao Liang, Lin Gao   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

PEMBANGKITAN DATA ACAK TERSEBAR DIRECT SEQUENCE SPREAD SPECTRUM PADA LAJU DATA BERKECEPATAN RENDAH UNTUK APLIKASI TEKNOLOGI CODE DIVISION MULTIPLE ACCESS

Jurnal Ilmiah SINERGI, 2017
Salah satu kelebihan utama sistem komunikasi Spread Spectrum adalah kemampuannya mengirimkan data informasi disertai kode-kode unik sehingga hanya perangkat penerima tertentu saya yang mampu mendeteksinya. Sangat banyak metode pembangkitan kode unik pada
Budi Herdiana, Muhammad Aria, Jana Utama
doaj   +1 more source

Performance analysis of direct-sequence spread-spectrum underwater acoustic communications based on at-sea data [PDF]

MATEC Web of Conferences, 2019
Direct sequence spread spectrum (DSSS) signal uses phase coherent signals where the information symbols are multiplied with a code sequence, commonly known as chips. The signals are processed at the receiver using the code sequence as a matched filter to
Du Pengyu, Wang Lujun, Zhang Hongtao, Xie Zhe   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Implementasi Direct Sequence Spread Spectrum pada DSK TMS320C6416T

Jurnal Teknik ITS, 2014
Spread spectrum merupakan teknik pengiriman sinyal yang tahan terhadap gangguan dan mempunyai tingkat keamanan informasi yang cukup tinggi pada saat pengiriman. Salah satu teknik spread spectrum yang dikembangkan adalah direct sequence.
Nanang Arif Haryadi, Suwadi Suwadi, Titiek Suryani   +2 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source