Results 111 to 120 of about 358,699 (263)
Advances in Civil EngineeringThe soils in the eastern region of Qinghai, China, are characterized by typical unsaturated loess with poor engineering properties, rendering them susceptible to geological disasters such as landslides.
Gang Wei +7 more
doaj +1 more source
A Direct-Based Method for Real-Time Transient Stability Assessment of Power Systems
, 2020 La stabilité du système d'alimentation est un problème qui met les ingénieurs des systèmes d'alimentation au défi depuis de nombreuses années. Cet article étudie l'évaluation de la stabilité transitoire à l'aide de méthodes directes par le critère de surface égale (EAC) et la fonction d'énergie transitoire (TEF).
Khazaee, Saeed +2 more
openaire +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2010 Direct damping rate measurements of AEs are obtained using the active MHD spectroscopy system installed on the JET tokamak. The system was recently equipped with new antennas, designed to study especially the modes of intermediate toroidal mode number n, |n| = 3 – 15, as the AEs of this range are most prone to destabilization by the fast particles in ...
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
INCOME TAX AND WAYS OF EVADING IT
Pravo, 2013 Income tax of legal entities falls within the group of direct taxes. The aim of the investigation is to determine the causes and consequences leading to tax evasion as well as the ways and forms serving the evasion of corporate income tax. Experiences of
Radica Šipovac +2 more
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