Results 91 to 100 of about 250,904 (303)

Combining Thermal Loading System with Acoustic Emission Technology to Acquire the Complete Stress-Deformation Response of Plain Concrete in Direct Tension. [PDF]

Materials (Basel), 2021
Zhang R, Guo L, Li W.
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Direct and Indirect Measurement of Complex Poisson's Ratio - Direct Measurement in Tension

This data set contains directly determined complex Poisson's ratio from axial and transversal strain measurements. Here, the axial and transverse strains were measured locally with strain gauges (K-CXY3-0015-3-350-O, HBK, Darmstadt, Germany) on cylindric
Steeb, Holger, Fauser, Dominik
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Surgical Treatment of Obstetric Plexus Lesions by Direct Coaptation Compared to Sural Nerve Graft Interposition

Journal of Brachial Plexus and Peripheral Nerve Injury
Background To date, there are no uniform guidelines for the treatment of obstetric plexus lesions in German-speaking countries. An end-to-end direct suture after resection of trunk neuroma is recommended for surgical treatment if tension-free ...
Justus Mai, Christa Kunigunde Raak, Thomas Ostermann, Jörg Bahm, Wolfram Scharbrodt   +4 more
doaj   +1 more source

Dynamic properties of stainless steel under direct tension loading using a simple gas gun

EPJ Web of Conferences, 2018
The combined experimental and theoretical approach was applied to the study of high-speed deformation and fracture of the 1810 stainless steel. The material tests were performed using a split Hopkinson pressure bar to determine dynamic stress-strain ...
Bragov Anatoly, Konstantinov Alexander, Kruszka Leopold, Lomunov Andrey, Filippov Andrey   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Directional Destress with Tension Blasting in Coal Mines

Procedia Engineering, 2017
Abstract In China, engineering geological disasters are frequently encountered in the underground mining sites where room and pillar method is used. This paper presents a novel method for developing the gateway tunnel without any excavation using directional tension blasting (DTB) in the mine panels. The mining-induced stress transfer will be blocked
Manchao He, Xiaohu Zhang, Shuai Zhao
openaire   +1 more source