Results 101 to 110 of about 250,904 (303)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Effect of Number of Layers on Tensile and Flexural Behavior of Cementitious Composites Reinforced with a New Sisal Fabric

open access: yesTextiles
The use of fabric in reinforcing cement-based materials expands their applications for various types of construction elements. Additionally, employing renewable sources of plant-based fabrics contributes to reducing the environmental impact of the ...
Adilson Brito de Arruda Filho   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

STRENGTH SHRINKAGE AND CREEP OF CONCRETE IN TENSION AND COMPRESSION

open access: yesCivil Engineering Dimension, 2006
Strength, shrinkage and creep of concrete in tension and compression have been determined and the relationship between those properties was studied. Direct tensile tests were applied to measure those properties in tension.
S A Kristiawan
doaj  

Direct Evidence for Curvature-Dependent Surface Tension in Capillary Condensation: Kelvin Equation at Molecular Scale

open access: yesPhysical Review X, 2018
Capillary condensation is the first-order vapor-to-liquid phase transition taking place in confined geometries. Such heterogeneous nucleation has been well described by thermodynamic laws such as the Kelvin equation, but the equation’s applicability at ...
Seongsoo Kim   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics

open access: yesCommunications Biology
Focal adhesions (FAs) are mechanosensitive structures that mediate force transmission between cells and the extracellular matrix. While Traction Force Microscopy (TFM) quantifies cellular tractions exerted on deformable substrates, Förster Resonance ...
Samet Aytekin   +10 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Bending Under Tension Test with Direct Friction Measurement

open access: yes, 2004
A special BUT-transducer has been developed in which friction around the tool radius can be directly measured when drawing a plane sheet strip around a cylindrical tool-pin under constant back tension.
Chodnikiewicz, K.   +3 more
core  

The Effects of Aggregate Sizes and Fiber Volume Fraction on Bending Toughness and Direct Tension of Steel Fiber Reinforced Concrete

open access: yes, 2012
In order to supplement the brittle property of concrete, fibers are added into concrete mixtures. Compared to general concrete, various characteristics such as tensile strength, bending strength, bending toughness, and resistance to crack are superior ...
Jae-Heum Moon   +2 more
core   +1 more source

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