Results 111 to 120 of about 1,378,738 (338)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Size effects and depolarization field influence on the phase diagrams of cylindrical ferroelectric nanoparticles

, 2006
Ferroelectric nanoparticles of different shape and their nanocomposites are actively studied in modern physics. Because of their applications in many fields of nanotechnology, the size effects and the possible disappearance of ferroelectricity at a ...
Anna N. Morozovska, Erdelyi, Eugene A. Eliseev, Fong, Freund, Glinchuk, Glinchuk, Glinchuk, Glinchuk, Huang, Jaffe, Kretschmer, Landau, Lines, Luo, Ma, Maya D. Glinchuk, Mishina, Mishra, Morrison, Pertsev, Rychetsky, Speck, Strukov, Tilley, Uchino, Wang, Yadlovker   +27 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effect of Number of Layers on Tensile and Flexural Behavior of Cementitious Composites Reinforced with a New Sisal Fabric

Textiles
The use of fabric in reinforcing cement-based materials expands their applications for various types of construction elements. Additionally, employing renewable sources of plant-based fabrics contributes to reducing the environmental impact of the ...
Adilson Brito de Arruda Filho, Paulo Roberto Lopes Lima, Ricardo Fernandes Carvalho, Otavio da Fonseca Martins Gomes, Romildo Dias Toledo Filho   +4 more
doaj   +1 more source

Weak temporal signals can synchronize and accelerate the transition dynamics of biopolymers under tension

, 2012
In addition to thermal noise, which is essential to promote conformational transitions in biopolymers, cellular environment is replete with a spectrum of athermal fluctuations that are produced from a plethora of active processes.
Bell, Bustamante, C. Hyeon, Cecconi, Doering, Dudko, Gammaitoni, Hyeon, H  nggi, Kim, Liphardt, McDonnell, Onoa, Onuchic, Pizzolato, Sanchez, Shaevitz, Shin, Smith, Stigler, Strick, Thirumalai, Visscher, W. K. Kim, W. Sung, Wen, Woodside, Zhou   +27 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Density Functional Theory of Inhomogeneous Liquids: II. A Fundamental Measure Approach

, 2008
Previously, it has been shown that the direct correlation function for a Lennard-Jones fluid could be modeled by a sum of that for hard-spheres, a mean-field tail and a simple linear correction in the core region constructed so as to reproduce the (known)
Balabanic C., Frenkel D., Hansen J.-P., Henderson D., James F. Lutsko, Steele W. A., van der Waals J. D.   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

STRENGTH SHRINKAGE AND CREEP OF CONCRETE IN TENSION AND COMPRESSION

Civil Engineering Dimension, 2006
Strength, shrinkage and creep of concrete in tension and compression have been determined and the relationship between those properties was studied. Direct tensile tests were applied to measure those properties in tension.
S A Kristiawan
doaj  

Spontaneous Emulsification as a Function of Material Exchange

Scientific Reports, 2017
Direct visualization at 1873 K of 0% to 8% molten FeAl droplets suspended in a SiO2 enriched oxide medium was carried out to image the evolution of droplet morphology during reaction between Al and SiO2. Phenomena such as perturbation growth, necking and
Stephen Spooner, Zushu Li, Seetharaman Sridhar   +2 more
doaj   +1 more source