Results 51 to 60 of about 58,702 (295)

Process Optimization and Distortion Prediction in Directed Energy Deposition

Journal of Manufacturing and Materials Processing
Directed energy deposition (DED), a form of additive manufacturing (AM), is gaining traction for its ability to produce complex metal parts with precise geometries.
Adem Ben Hammouda, Hatem Mrad, Haykel Marouani, Ahmed Frikha, Tikou Belem   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Tailoring microstructure using pulsed electromagnetic field-assisted directed energy deposition

Materials Today Advances
Despite the advancements in laser directed energy deposition, challenges such as micro-segregation, formation of hard and brittle phases, and poor controllability over solidification microstructures persist due to the rapid melting-solidification ...
Hao Fang, Pengzhi Zhang, Honghao Ge, Jang Griffin, Gang Dong, Huaping Wu, Liang Wang, Jianhua Yao, Chinnapat Panwisawas   +8 more
doaj   +1 more source

Multi-faceted monitoring of powder flow rate variability in directed energy deposition

Additive Manufacturing Letters, 2022
Powder flow rate is a key parameter in Directed Energy Deposition (DED) processes. During a typical build, if powder flow rate is reduced for just 1 second, 30 mm of melt track is affected.
Felicity S.H.B. Freeman, B Thomas, L Chechik, Iain Todd   +3 more
doaj   +1 more source

A novel directed energy deposition-arc method of deposition layer without focused thermal energy heating: droplet transfer, morphology and microstructure

, 2023
Additive manufacturing (AM) of metal usually forms columnar grains along the building direction due to the focused thermal energy directly heating the deposition layer to easily obtain an obvious temperature gradient.
Shupeng Wang, Xiaohui Zhao, Xiaoyu Sun, Chao Chen, Bin Yang, Tianting Feng   +5 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Overlapping in Wire-arc Directed Energy Deposition Using Rotating Electrode

International Journal of Technology
Adoption of additive manufacturing has enabled the fabrication of high-performance components with complex geometries. Tungsten Inert Gas (TIG) welding technology has been introduced to enhance the mechanical properties of the final products; however, it
Andrea Bimbi, Yuta Sugiyama, Masahiro Kawabata, Hiroyuki Sasahara   +3 more
doaj   +1 more source

Inconel 718 two ways: Powder bed fusion vs. directed energy deposition

Additive Manufacturing Letters, 2023
Additive manufacturing (AM) research has grown massively in the last few decades, with applications ranging from the medical sector to automotive. AM of nickel superalloys is of great interest for the aerospace sector due to their mechanical performance ...
Lova Chechik, Iain Todd
doaj   +1 more source

Utilisation of artificial neural networks to rationalise processing windows in directed energy deposition applications

, 2021
Utilisation of artificial neural networks to rationalise processing windows in directed energy deposition ...
A Molotnikov (13456158), Nick Birbilis (14681953), DR Feenstra (16878528)   +2 more
core