Results 91 to 100 of about 608,783 (278)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Interleaved adjoints of directed graphs
European Journal of Combinatorics, 2011 For an integer k >= 1, the k-th interlacing adjoint of a digraph G is the digraph i_k(G) with vertex-set V(G)^k, and arcs ((u_1, ..., u_k), (v_1, ..., v_k)) such that (u_i,v_i) \in A(G) for i = 1, ..., k and (v_i, u_{i+1}) \in A(G) for i = 1, ..., k-1.
Jan Foniok +2 more
openaire +4 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Twin minus domination numbers in directed graphs
Communications in Combinatorics and Optimization, 2016 Let $D=(V,A)$ be a finite simple directed graph. A function $f:V\longrightarrow \{-1,0,1\}$ is called a twin minus dominating function if $f(N^-[v])\ge 1$ and $f(N^+[v])\ge 1$ for each vertex $v\in V$. The twin minus domination number of
M. Atapour, A. Khodkar
doaj +1 more source
Operator machines on directed graphs
, 2009 We show that if an infinite-dimensional Banach space X has a symmetric basis then there exists a bounded, linear operator R : X --> X such that the set A = {x in X : ||R^n(x)|| --> infinity} is non-empty and nowhere dense in X.
Hajek, Petr, Smith, Richard J.
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
On Making Directed Graphs Transitive
Journal of Computer and System Sciences, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Mathias Weller +3 more
openaire +1 more source