Results 81 to 90 of about 1,263,669 (205)

From Path Graphs to Directed Path Graphs

open access: yes, 2010
International audienceWe present a linear time algorithm to greedily orient the edges of a path graph model to obtain a directed path graph model (when possible). Moreover we extend this algorithm to find an odd sun when the method fails.
Marisa Gutierrez   +9 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Dynamic Economic Relationships Among U.S. Soy Product Markets: Using a Cointegrated Vector Autoregression Approach with Directed Acyclic Graphs [PDF]

open access: yes
This paper applies a combined methodology of a recently developed directed acyclic graph (DAG) analysis with Johansen and Juselius' methods of the cointegrated vector autoregression (VAR) model to a monthly U.S.
Rogowsky, Robert A.   +2 more
core  

Characterizing bearing equivalence in directed graphs [PDF]

open access: yes, 2023
In this paper, we study bearing equivalence in directed graphs. We first give a strengthened definition of bearing equivalence based on the \textit{kernel equivalence} relationship between bearing rigidity matrix and bearing Laplacian matrix.
Sun, Zhiyong   +2 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Fast directed q-analysis for brain graphs

open access: yesBrain Organoid and Systems Neuroscience Journal
Recent innovations in reconstructing large scale, full-precision, neuron-synapse-level connectomes demand subsequent improvements to graph analysis methods, to keep up with the growing complexity and size of the data.
Felix Windisch, Florian Unger
doaj   +1 more source

Finding Hamilton cycles in robustly expanding digraphs

open access: yesJournal of Graph Algorithms and Applications, 2012
We provide an NC algorithm for finding Hamilton cycles in directed graphs with a certain robust expansion property. This property captures several known criteria for the existence of Hamilton cycles in terms of the degree sequence and thus we provide ...
Demetres Christofides   +3 more
doaj   +1 more source

Random Directed Graph Distributions in the Triad Census in Social Networks [PDF]

open access: yes
This paper uses the concept of the triad census first introduced by Holland and Leinhardt, and describes several distributions on directed graphs. Methods are presented for calculating the mean and the covariance matrix of the triad census for the ...
Stanley S. Wasserman
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

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