Results 71 to 80 of about 1,830,098 (281)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Survey of Search Strategies in the Dynamic Symbolic Execution

ITM Web of Conferences, 2017
Dynamic symbolic execution (DSE) is an important way to discover software vulnerabilities. One key challenge in DSE is to find proper paths in the huge program execution space to generate effective inputs.
Liu Yu, Zhou Xu, Gong Wei-Wei
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Incremental embodied chaotic exploration of self-organized motor behaviors with proprioceptor adaptation [PDF]

, 2015
This paper presents a general and fully dynamic embodied artificial neural system, which incrementally explores and learns motor behaviors through an integrated combination of chaotic search and reflex learning.
Aida, Akazawa, Asai, Asai, Barlas, Bronsing, Cohen, Conway, Davis, Davis, Dietz, Doya, Eiben, Ekeberg, Fernando, Fitzhugh, Freeman, Goulding, Grillner, Guevara, Hanson, Hill, Hodgkin, Hoerzer, Jean-Xavier, Johnson, Kinjo, Kuniyoshi, Kuniyoshi, Legenstein, Marques, McGregor, Nagumo, Nishimura, Ohgi, Pearson, Pearson, Pelikan, Petersson, Pfeifer, Pfeifer, Pitti, Prochazka, Rapp, Riley, Rosenstein, Schouenberg, Shim, Shim, Shim, Shim, Skarda, Smith, Steingrube, Terman, Turrigiano, Turrigiano, Wheeler, Wolf, Wolpaw, Wolpaw, Wright   +61 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Directed search and job rotation [PDF]

In this note, we consider the impact of job rotation in a directed search model in which firm sizes are endogenously determined, and match quality is initially unknown.
Li, Fei, Tian, Can
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Price Dispersion with Directed Search. [PDF]

We study a market where identical capacity-constrained sellers compete to attract identical buyers, via price advertisements. Once buyers reach a store, prices might be renegotiable in a manner that is responsive to excess demand.
Camera, Gabriele, Selcuk, Cemil
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Search Intensity, Directed Search And The Wage Distribution [PDF]

We propose a search equilibrium model in which homogenous …rms post wages along with a vacancy to attract job-seekers, while homogenous unemployed workers invest in costly job-seeking.
André Zylberberg, Bruno Decreuse
core