Generative dramaturgy : a strategy for refocusing directorial intent in the translation phase of play development [PDF]
, 2008 Includes abstract.Includes bibliographical references (leaves 36-40).This explication focuses on the director working collaboratively in the ensemble towards generating new material inspired by the play text in the staging of the play.
Kirch, Michael A
core
Palladium-catalyzed regioselective C1-selective nitration of carbazoles
Beilstein Journal of Organic ChemistryCarbazoles are ubiquitous and privileged heterocyclic scaffolds in various functional organic materials and naturally occurring products. Although extensive efforts have focused on developing synthetic strategies toward carbazole derivatives, direct ...
Vikash Kumar +5 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A Biologist’s View of Individual Cultural Identity for the Study of Cities [PDF]
The behaviour of urban populations is compared with the systems directing behaviour in individuals. This is both a metaphor and a mechanistic parallel. The biological model draws upon recent developments in brain research and psychological and cultural ...
Richard Pearce
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Enantioselective Hydroalkenylation and Hydroalkynylation of Alkenes Enabled by a Transient Directing Group: Catalyst Generality through Rigidification. [PDF]
Angew Chem Int Ed Engl, 2023 Simlandy AK +7 more
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Geminal group-directed olefinic C-H functionalization via four- to eight-membered exo-metallocycles
Nature Communications, 2019 Identifying distinct cyclometallation pathways is essential to new types of C-H activation and functionalization in organic synthesis. Here, the authors show the activation of an olefinic C-H bond geminal to the directing group via four- to eight ...
Keke Meng +5 more
doaj +1 more source
Directing-Group-Free Arene C(sp2)-H Amination Using Bulky Aminium Radicals and DFT Analysis of Regioselectivity. [PDF]
J Org Chem, 2023 Behnke NE +4 more
europepmc +1 more source