Results 131 to 140 of about 9,246,440 (304)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Geminal group-directed olefinic C-H functionalization via four- to eight-membered exo-metallocycles
Nature Communications, 2019 Identifying distinct cyclometallation pathways is essential to new types of C-H activation and functionalization in organic synthesis. Here, the authors show the activation of an olefinic C-H bond geminal to the directing group via four- to eight ...
Keke Meng +5 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Antea Group Archeolgoie 2019/15
, 2020 Antea Group projectnummer 433403 Antea Group heeft in de 17 juli 2018 tot 3 augustus 2018 een archeologisch veldonderzoek (Opgraving, variant archeologische begeleiding) uitgevoerd aan het Achterom te Groningen.
Akkerman, E. (Antea Group) +2 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Enantioselective Hydroalkenylation and Hydroalkynylation of Alkenes Enabled by a Transient Directing Group: Catalyst Generality through Rigidification. [PDF]
Angew Chem Int Ed Engl, 2023 Simlandy AK +7 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
High-resolution directed human connectomes and the Consensus Connectome Dynamics.
PLoS ONE, 2019 Here we show a method of directing the edges of the connectomes, prepared from HARDI datasets from the human brain. Before the present work, no high-definition directed braingraphs were published, because the tractography methods in use are not capable ...
Balázs Szalkai +3 more
doaj +1 more source
Directing-Group-Free Arene C(sp2)-H Amination Using Bulky Aminium Radicals and DFT Analysis of Regioselectivity. [PDF]
J Org Chem, 2023 Behnke NE +4 more
europepmc +1 more source
Antea Group Archeologie 2017/154
, 2020 Antea projectnummer 419284 In september en oktober 2017 heeft Antea Group een archeologische begeleiding uitgevoerd ter plaate van een gasleidingtracé in de omgeving van Niehove (gemeente Zuidhorn): twee wierdeterreinen bij Frytum, één bij Enuma en een ...
Fens, R. (Antea Group) +1 more
core +1 more source