Results 111 to 120 of about 19,002,772 (320)

Exogenous Directing Group Free, Ligand-Enabled gamma-C(sp3)–H Arylation of Free Primary Aliphatic Amines and α-Amino Esters

open access: yes, 2019
A Pdᴵᴵ-catalyzed, ligand-enabled gamma-C(sp3)–H arylation of free primary aliphatic amines and amino esters without using an exogenous directing group is reported.
Gang, Li   +4 more
core   +1 more source

On directed interpolation groups [PDF]

open access: yesCzechoslovak Mathematical Journal, 1990
Radical classes of lattice-ordered groups (\(\ell\)-groups) have been the subject of many researchers in recent years most notably the present author. Here, an important extension of these ideas is introduced in the study of radical classes of directed interpolation groups. [See \textit{L. Fuchs}, Ann. Sc. Norm. Sup. Pisa, Cl. Sci. Fis. Mat., III. Ser.
openaire   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Cowboys Directing a Group of Cattle

open access: yes, 1915
A sepia photograph depicting two unidentified cowboys on horseback, directing a group of cows in front them a certain ...
Dixon, Maynard
core   +2 more sources

A unified approach for divergent synthesis of contiguous stereodiads employing a small boronyl group

open access: yesNature Communications, 2020
Predictable and unified approaches to all possible stereoisomers of acyclic compounds with contiguous stereocentres are rare. Here, the authors disclose a divergent α-functionalization of enolates with either syn or anti selectivity employing a β-boronyl
Miao Zhan   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Inherent directing group enabled, Co(III)-catalyzed C-H allylation/ vi-nylation of isoquinolones

open access: yes
The site-selective C8-allylation and vinylation of isoquinolones have been accomplished using allyl acetate and vinyl acetate and oxo group of isoquinolone as an inherent directing group in the presence of Co(III) catalysis. A plausible mechanism for the
Tamanna , Sharma   +3 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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