Results 121 to 130 of about 19,002,772 (320)

KOMPETENSI MANAJERIAL KONSELOR PADA LAYANAN KONSELING KELOMPOK

open access: yesAl-Tanzim: Jurnal Manajemen Pendidikan Islam, 2019
The purpose of this study was to determine the managerial ability of the counselor in implementing group counseling at school. The research method used is qualitative, data analysis used is drawing conclusions based on Lawrence's theory.
Dody Riswanto
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Ligand-enabled Ni-catalysed dicarbofunctionalisation of alkenes with diverse native functional groups

open access: yesNature Communications
The transition metal-catalysed dicarbofunctionalisation of unactivated alkenes normally requires exogenous strong coordinated directing groups, thus reducing the overall reaction efficiency.
Dao-Ming Wang   +7 more
doaj   +1 more source

Pd(II)-catalysed meta-C–H functionalizations of benzoic acid derivatives

open access: yesNature Communications, 2016
While directed ortho-metalation is a well-established protocol, meta-functionalisation of aromatic groups is more challenging. Here, the authors report a directed meta-C-H functionalisation of benzoic acid derivatives, using a nitrile-based sulfonamide ...
Shangda Li   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization

open access: yesNature Communications, 2017
C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to ...
Wei Shu   +3 more
doaj   +1 more source

Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines.

open access: yesOrganic Letters, 2018
The transient directing group promoted C(sp2)-H functionalization of benzaldehydes with anthranils by a cationic rhodium(III) catalyst is described. Notably, anthranils have been used as both transient directing groups and amination sources to afford 2 ...
Saegun Kim   +7 more
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Palladium-catalyzed regioselective C1-selective nitration of carbazoles

open access: yesBeilstein Journal of Organic Chemistry
Carbazoles are ubiquitous and privileged heterocyclic scaffolds in various functional organic materials and naturally occurring products. Although extensive efforts have focused on developing synthetic strategies toward carbazole derivatives, direct ...
Vikash Kumar   +5 more
doaj   +1 more source

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