Results 121 to 130 of about 679,253 (302)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Directing group assisted para-selective C-H alkynylation of unbiased arenes enabled by rhodium catalysis. [PDF]

Chem Sci, 2023
Dutta U, Prakash G, Devi K, Borah K, Zhang X, Maiti D.   +5 more
europepmc   +1 more source

A study to define the need for integrating elements of administration into the basic curriculum of professional nurse education [PDF]

, 1958
Thesis (M.S.)--Boston ...
Defenderfer, Julia B.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes. [PDF]

Nat Chem, 2022
Wang H, Liu CF, Martin RT, Gutierrez O, Koh MJ.   +4 more
europepmc   +1 more source

Closed loop fiber optic rotation sensor [PDF]

, 1987
An improved optical gyroscope is provided, of the type that passes two light components in opposite directions through an optic fiber coil, and which adds a small variable frequency to one of the light components to cancel the phase shift due to rotation
Bartman, Randall K., Goss, Willis C., Nerheim, Noble M., Youmans, Bruce R.   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

High-resolution directed human connectomes and the Consensus Connectome Dynamics.

PLoS ONE, 2019
Here we show a method of directing the edges of the connectomes, prepared from HARDI datasets from the human brain. Before the present work, no high-definition directed braingraphs were published, because the tractography methods in use are not capable ...
Balázs Szalkai, Csaba Kerepesi, Bálint Varga, Vince Grolmusz   +3 more
doaj   +1 more source

An endo-Directing-Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes. [PDF]

Angew Chem Int Ed Engl, 2022
Sokolova OO, Bower JF.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source