Results 61 to 70 of about 714,041 (272)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Spatially localized direction of arrival estimation

Proceedings : European Conference on Noise Control, 2018
Direction-of-arrival (DOA) estimation is a fundamental area of research in the field of array processing, as it applies in a variety of areas, including: sound field analysis, spatial sound reproduction and spatial filtering. There exists a plethora of DOA estimating algorithms, which all vary in terms of accuracy and computational complexity.
Delikaris-Manias, Symeon, McCormack, Leo, Pavlidi, Despoina, Mouchtaris, Athanasios   +3 more
openaire   +3 more sources

High-Order Maximum Likelihood Methods for Direction of Arrival Estimation

IEEE Open Journal of Signal Processing, 2021
It is shown that using high-order statistics (higher than two) is beneficial in subspace-based Direction Of Arrival (DOA) estimation methods. Particularly, the high-order MUltiple SIgnal Classification (MUSIC) method, also known as $ 2q$-MUSIC method ...
Mohammadhossein Barat, Mahmood Karimi, Mohammad Masnadi-Shirazi   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Noncircular coherent signal direction of arrival estimation for coprime array: A subspace‐based interpolation approach

IET Radar, Sonar & Navigation
To address the array aperture loss caused by mainstream direction of arrival (DOA) estimation algorithms for coherent signals using matrix interpolation techniques, a non‐circular (NC) coherent signal direction‐finding method that fully utilises ...
Zihan Shen, Hao Hu, Jiaqi Li, Xiaofei Zhang   +3 more
doaj   +1 more source

A high-resolution DOA estimation method for deep-sea multipath coherent channels [PDF]

Zhihui kongzhi yu fangzhen
Aiming at the problem of error in deep-sea DOA(Direction of Arrival, DOA) estimation based on plane wave sound field model, this paper establishes the array signal model of deep-sea DOA estimation under multipath channel based on ray theory.
CAO Yongjie, MAO Weining
doaj   +1 more source

Total Least Squares Method for Direction of Arrival Estimation [PDF]

Jisuanji gongcheng, 2019
In the Time Difference of Arrival(TDOA) positioning technology,when the position coordinates of the sensor have errors,the estimated value obtained by the Least Squares(LS) method no longer has the best unbiasedness,resulting in a decrease in the ...
WANG Hai, ZHANG Menghan, CUI Xunxue
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source