Results 41 to 50 of about 2,491,696 (297)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Solutions for Multitime Reaction–Diffusion PDE

Mathematics, 2022
A previous paper by our research group introduced the nonlinear multitime reaction–diffusion PDE (with oblique derivative) as a generalized version of the single-time model.
Cristian Ghiu, Constantin Udriste
doaj   +1 more source

An improved regularity criterion for the Navier–Stokes equations in terms of one directional derivative of the velocity field

, 2018
In this paper, we establish a new multiplicative Sobolev inequality. As applications, we refine and extend the results in Kukavica and Ziane (J Math Phys 48:065203, 2007) and Cao (Discrete Contin Dyn Syst 26:1141–1151, 2010) simultaneously.
Zu-Jin Zhang
semanticscholar   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Nonlinear Directional Derivative Scheme for Edge Detection [PDF]

, 2012
In this paper, a new one-stage nonlinear directional derivative scheme has been proposed for edge detection. The directional edge detection method was applied to gray and color images.
Catak, Muammer
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Design optimization of multi-objective proportional–integral–derivative controllers for enhanced handling quality of a twin-engine, propeller-driven airplane

Advances in Mechanical Engineering, 2020
Herein, the design optimization of multi-objective controllers for the lateral–directional motion using proportional–integral–derivative controllers for a twin-engine, propeller-driven airplane is presented.
Mohsen Rostami, Joon Chung, Hyeong Uk Park   +2 more
doaj   +1 more source

Some relationships among gw-subdifferential, directional derivative and radial epiderivative for nonconvex vector functions

, 2013
WOS: 000349314300005In this work, we give some characterizations of gw-subdifferentiability of a vector-valued function by using its directional derivative and radial epiderivative.
Küçük, Yalçın, Küçük, Mahide, Güvenc, İlknur Atasever, Mahide Küçük, İlknur Atasever Güvenç, Yalçın Küçük   +5 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source