Letter to the Editor Regarding: “Real-World Analysis Affirms the High Persistence and Adherence Observed with Diroximel Fumarate in Patients with Multiple Sclerosis” [PDF]
Neurology and Therapy, 2023 Pelayo Nieto-Gómez +1 more
doaj +2 more sources
Safety and effectiveness of diroximel fumarate in relapsing forms of multiple sclerosis: a systematic review and meta-analysis. [PDF]
Neurol SciAbstract Objective To evaluate the safety and efficacy of Diroximel Fumarate (DRF) in patients with different relapsing forms of MS (RMS) through systematic review and meta-analysis. Methods A systematic review and meta-analysis adhering to PRISMA guidelines was conducted.
Sabet H +7 more
europepmc +3 more sources
Fumarate-based drugs protect against neuroinflammation via upregulation of anti-ferroptotic pathways [PDF]
Journal of NeuroinflammationFerroptosis is defined as iron dependent non-apoptotic cell death. It is based on peroxidation of polyunsaturated phospholipids and subsequent membrane rupture.
Katinka Fischer +10 more
doaj +2 more sources
18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate. [PDF]
Brain Behav ImmunNeuroimmune signaling is a key process underlying neuropathic pain. Clinical studies have demonstrated that 18 kDa translocator protein (TSPO), a putative marker of neuroinflammation, is upregulated in discrete brain regions of patients with chronic pain.
Cazuza RA +7 more
europepmc +3 more sources
Crystal Structures of Large-Volume Commercial Pharmaceuticals [PDF]
Structural DynamicsAs part of a continuing project, the room-temperature crystal structures of 17 commercial pharmaceutical APIs have been solved and refined using synchrotron X-ray powder diffraction data (11-BM at APS and Wiggler Low Energy Beamline at CLS), and ...
James A Kaduk +2 more
doaj +2 more sources
Brain DisordersObjective: Dimethyl fumarate (DMF) and diroximel fumarate (DRF) are oral multiple sclerosis (MS) disease-modifying therapies (DMTs). Absolute lymphocyte count (ALC) dynamics are similar for DMF and DRF, but have not been investigated in patients who ...
Shauna M. Gales +9 more
doaj +2 more sources
Response to Letter to the Editor Regarding “Real-World Analysis Affirms the High Persistence and Adherence Observed with Diroximel Fumarate in Patients with Multiple Sclerosis” [PDF]
Neurology and Therapy, 2023 Brittney Lager +6 more
doaj +2 more sources
Comparative Effectiveness of Fumarates Versus Sphingosine-1-Phosphate Receptor Modulators in Black Patients with Multiple Sclerosis [PDF]
Neurology and TherapyIntroduction Multiple sclerosis (MS) is a heterogeneous disease that disproportionately impacts Black people with MS (PwMS), who experience more severe disease and higher relapse rates compared with non-Black populations.
Sophia Woodson +12 more
doaj +2 more sources
Natalizumab and fumarate treatment differentially modulate CD4+ T cell and B cell subtypes in multiple sclerosis patients without impacting durable COVID-19 vaccine responses [PDF]
Frontiers in ImmunologyBackgroundThere is a greater risk of complications from severe COVID-19 in immunocompromised patients with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs), as well as a diminished vaccine response.MethodsIn this ...
Ryan Curtin +33 more
doaj +2 more sources