Results 41 to 50 of about 2,286,544 (361)

Employers and the ADA: Myths and Facts [PDF]

open access: yes, 2005
[Excerpt] The Americans with Disabilities Act (ADA) is a landmark federal law that protects the rights of people with disabilities by eliminating barriers to their participation in many aspects of living and working in America.
Office of Disability Employment Policy
core   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Customized Solutions for Today\u27s Workforce: The Job Accommodation Network [PDF]

open access: yes, 2005
[Excerpt] The Job Accommodation Network (JAN) is a free and confidential consulting service for employers that expands employment opportunities for individuals with disabilities by providing: ■ Individualized worksite accommodation solutions ■ Technical ...
Office of Disability Employment Policy
core   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

open access: yesFEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu   +6 more
wiley   +1 more source

Cultivating Leadership: Mentoring Youth with Disabilities [PDF]

open access: yes, 2005
[Excerpt] A mentor is a person who through support, counsel, friendship, reinforcement and constructive example helps another person, usually a young person, to reach his or her work and life goals.
Office of Disability Employment Policy
core   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

open access: yesFEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu   +6 more
wiley   +1 more source

Job Accommodation Network (JAN) Brochure [PDF]

open access: yes, 2006
[Excerpt] JAN is the nation’s premier source for information on job accommodations. Started in 1983, JAN responds to more than 32,000 inquiries annually from employers, job seekers and employees with disabilities and their families as well as service ...
Office of Disability Employment Policy
core   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

open access: yesFEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji   +3 more
wiley   +1 more source

Focus on Ability: Interviewing Applicants with Disabilities [PDF]

open access: yes, 2005
[Excerpt] As employers well know, the job interview plays a critical role in the hiring process, allowing them the opportunity to identify the individual who possesses the best mix of knowledge, skills and abilities for the position available.
Office of Disability Employment Policy
core   +1 more source

Risk analysis of the Unity 1.5T MR‐Linac adapt‐to‐shape workflow

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background and Purpose The adapt‐to‐shape (ATS) workflow on the Unity MR‐Linac (Elekta AB, Stockholm, Sweden) allows for full replanning including recontouring and reoptimization5. Additional complexity to this workflow is added when the adaptation involves the use of MIM Maestro (MIM Software, Cleveland, OH) software in conjunction with ...
Jiayi Liang   +13 more
wiley   +1 more source

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