Results 41 to 50 of about 793,248 (269)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Early Check: translational science at the intersection of public health and newborn screening

BMC Pediatrics, 2019
Background Newborn screening (NBS) occupies a unique space at the intersection of translational science and public health. As the only truly population-based public health program in the United States, NBS offers the promise of making the successes of ...
Donald B. Bailey, Lisa M. Gehtland, Megan A. Lewis, Holly Peay, Melissa Raspa, Scott M. Shone, Jennifer L. Taylor, Anne C. Wheeler, Michael Cotten, Nancy M. P. King, Cynthia M. Powell, Barbara Biesecker, Christine E. Bishop, Beth Lincoln Boyea, Martin Duparc, Blake A. Harper, Alex R. Kemper, Stacey N. Lee, Rebecca Moultrie, Katherine C. Okoniewski, Ryan S. Paquin, Denise Pettit, Katherine Ackerman Porter, Scott J. Zimmerman   +23 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Evaluation of telemental health services for people with intellectual and developmental disabilities: protocol for a randomized non-inferiority trial

BMC Health Services Research, 2023
Background Roughly 40% of those with intellectual/developmental disabilities (IDD) have mental health needs, twice the national average. Unfortunately, outpatient mental health services are often inaccessible, increasing reliance on hospital-based ...
Luther G. Kalb, Jessica M. Kramer, Tawara D. Goode, Sandra J. Black, Susan Klick, Andrea Caoili, Samantha Klipsch, Ann Klein, Micah P. Urquilla, Joan B. Beasley   +9 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Impact of a disability-targeted microentrepreneurship programme in Kenya: study protocol for a randomised controlled trial of the InBusiness programme

Trials, 2023
Background There is a lack of evidence on the effectiveness of livelihood interventions amongst people with disabilities. In many countries, self-employment or microentrepreneurship is a dominant source of livelihoods for people with disabilities and ...
Lena Morgon Banks, Stella Kepha, Anja Zinke-Allmang, Paul M. Gichuki, Nathaniel Scherer, Charles Mwandawiro, Mark Carew, Doris Njomo, Shanquan Chen, Collins Okoyo, Calum Davey, Tom Shakespeare, Maria Antonella Pereira, Divya Goyal, Hannah Kuper   +14 more
doaj   +1 more source

Deep Learning Algorithms to Identify Autism Spectrum Disorder in Children-Based Facial Landmarks

Applied Sciences, 2023
People with autistic spectrum disorders (ASDs) have difficulty recognizing and engaging with others. The symptoms of ASD may occur in a wide range of situations. There are numerous different types of functions for people with an ASD.
Hasan Alkahtani, Theyazn H. H. Aldhyani, Mohammed Y. Alzahrani   +2 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Rule of law - wishful thinking? Exemptions from educational requirements and the use of coercion against people with intellectual disability

Scandinavian Journal of Disability Research, 2010
The article focuses on two conditions related to the use of coercion vis-á-vis persons with intellectual disabilities in Norway. The first condition concerns the widespread use of exemptions from legally binding educational requirements.
Karl Elling Ellingsen, Kim Berge, Dirk Lungwitz   +2 more
doaj   +1 more source