Results 31 to 40 of about 848,368 (315)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Health-related quality of life among lower limb amputees using prostheses in Nepal: a cross-sectional study

BMC Sports Science, Medicine and Rehabilitation
Introduction Lower limb amputation significantly impacts individuals’ quality of life, with prostheses playing a crucial role in rehabilitation and mobility restoration.
Bibek Banskota, Rajan Bhusal, Niraj Bhattarai, Yam Prakash Gurung, Prakash Kumar Yadav, Ashok Kumar Banskota   +5 more
doaj   +1 more source

Application of the International Classification of Functioning, Disability and Health in Assessment of Integrated Rehabilitation of Disabled People [PDF]

Клиническая и специальная психология, 2017
The article presents the possibility of applying the International Classification of Functioning, Disability and Health (ICF) in assessing the rehabilitation process in the conditions of the regional center for the social rehabilitation of disabled ...
Lorer V., Zhukova T.
doaj   +1 more source

The dynamics of being disabled [PDF]

, 2000
Government policies on disability - and criticism of them - rest in part on an understanding of the circumstances of disabled people informed by cross-sectional survey data, dividing the population into 'the disabled' and 'the non-disabled'.
Burchardt, Tania
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effectiveness of supracondylar dome osteotomy in reducing lateral condylar prominence and enhancing functional outcomes in pediatric cubitus varus: a retrospective study

BMC Musculoskeletal Disorders
Background Cubitus varus, a common complication of pediatric supracondylar humerus fractures, presents with internal rotation, extension, and varus angulation.
Yam Prakash Gurung, Sabin Pokharel, Rajan Bhusal, Tarun Rajbhandari, Ashok Kumar Banskota, Bibek Banskota   +5 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Artificial intelligence in orthopaedic education, training and research: a systematic review

BMC Medical Education
Background Artificial intelligence (AI) increasingly transforms orthopedic education and research, offering novel surgical training and scientific advancement approaches.
Bibek Banskota, Rajan Bhusal, Prkash Kumar Yadav, Ashok Kumar Banskota   +3 more
doaj   +1 more source

The use of functional activities in therapy: An integration of the principles of motor control and the learning process

South African Journal of Physiotherapy, 1996
The successful rehabilitation of a patient following a CVA is largely dependent on the effective relearning of previous motor skills or the learning of new skills. An understanding of the components of motor function and control and the principles of the
E. S. Bakkes, S. J. Groenewald, J. R. Hughes   +2 more
doaj   +1 more source

Ötekileştirilmiş Beden ya da Engelliler: Sosyolojik Bir Değerlendirme

Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2023
Bu çalışma, günümüzde ve bütün dünyada önemli konulardan biri olan engellilik meselesini ele alan teorik bir çalışmadır. Çalışmada engellilere yönelik tutumlar ve görüşler sosyolojik açıdan incelenir. Bu bağlamda bedenin ötekileştirilmesi ve yeniden inşa
Zhanargul Pangalıyeva, Bengül Güngörmez Akosman   +1 more
doaj   +1 more source