Results 71 to 80 of about 1,033,986 (310)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Overcoming Expert Disagreement In A Delphi Process. An Exercise In Reverse Epistemology [PDF]
, 2015 Disagreement among experts is a central topic in social epistemology. What should an expert do when confronted with the different opinion of an epistemic peer?
Elisabetta, Lalumera
core +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The European Journal of Humour Research, 2015 In the vernacular ideology of humour there are definite ideas about where the limits of joke acceptability lie. In practice, many joke performances seem to go beyond those limits and yet arouse little if any opposition. This paper considers the role that
Moira Marsh
doaj
Opinion fluctuations and disagreement in social networks [PDF]
, 2012 We study a tractable opinion dynamics model that generates long-run disagreements and persistent opinion fluctuations. Our model involves an inhomogeneous stochastic gossip process of continuous opinion dynamics in a society consisting of two types of ...
Acemoglu, Daron +3 more
core +3 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Members of different social groups often hold widely divergent public beliefs regarding the nature of the world in which they live. We develop a model that can accommodate such public disagreement, and use it to explore questions concerning the ...
Muhamet Yildiz, Rajiv Sethi
core
Relativism, Faultlessness, and the Epistemology of Disagreement [PDF]
, 2018 : Recent years have witnessed a revival of interest in relativism. Proponents have defended various accounts that seek to model the truth-conditions of certain propositions along the lines of standard possible world semantics.
Dugas, Micah
core