Results 91 to 100 of about 1,033,986 (310)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The Self-Undermining Arguments from Disagreement [PDF]
, 2019 Arguments from disagreement against moral realism begin by calling attention to widespread, fundamental moral disagreement among a certain group of people. Then, some skeptical or anti-realist-friendly conclusion is drawn.
Sampson, Eric
core
When Conciliation Frustrates the Epistemic Priorities of Groups [PDF]
, 2021 Our aim in this chapter is to draw attention to what we see as a disturbing feature of conciliationist views of disagreement. Roughly put, the trouble is that conciliatory responses to in-group disagreement can lead to the frustration of a group's ...
Skipper, Mattias +1 more
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Consensos sobre la naturaleza de la ciencia: fundamentos de una investigación empírica [PDF]
Revista Eureka sobre Enseñanza y Divulgación de las Ciencias, 2007 The issues about the nature of science are today considered a core content of the scientific and technological literacy for all. However, the inclusion of the nature of science in the science school curriculum is not easy and requires some conditions ...
Acevedo-Díaz, J.A.; +3 more
doaj
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Consensus problems in networks of agents with switching topology and time-delays [PDF]
, 2003 In this paper, we discuss consensus problems for networks of dynamic agents with fixed and switching topologies. We analyze three cases: 1) directed networks with fixed topology; 2) directed networks with switching topology; and 3) undirected networks ...
Murray, Richard M., Olfati-Saber, Reza
core +1 more source
Minimizing Polarization and Disagreement in Social Networks
, 2017 The rise of social media and online social networks has been a disruptive force in society. Opinions are increasingly shaped by interactions on online social media, and social phenomena including disagreement and polarization are now tightly woven into ...
Musco, Cameron +2 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Evolution of the interpersonal conflict paradigm
Judgment and Decision Making, 2008 Using Brunswik’s (1952) lens model framework, Hammond (1965) proposed interpersonal conflict theory to explain the nature, source, and resolution of disagreement or “cognitive conflict” between parties performing judgment tasks.
Mandeep K. Dhami, Henrik Olsson
doaj +1 more source