Results 151 to 160 of about 1,303,041 (346)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Characterization of Normal and Degenerative Discovertebral Complexes Using Qualitative and Quantitative Magnetic Resonance Imaging at 4.7T: Longitudinal Evaluation of Immature and Mature Rats

open access: yesBioengineering
Purpose: We assessed the feasibility of qualitative, semiquantitative, and multiparametric quantitative magnetic resonance imaging (MRI) using a three-dimensional (3D) ultrashort echo time (3D-UTE) sequence together with 2D-T2 and 3D-T1 mapping sequences
Benjamin Dallaudière   +6 more
doaj   +1 more source

The influence of seasons on craniocerebral chronic vascular diseases, cervical spondylosis, herpes zoster, knee osteoarthritis, lumbar disc disease: a retrospective analysis [PDF]

open access: hybrid, 2020
Zong‐Jin Gan   +11 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

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