Results 61 to 70 of about 40,194 (357)

Bicycle Disc Brake Thermal Performance: Combining Dynamometer Tests, Bicycle Experiments, and Modeling

Proceedings, 2020
High-power bicycle disc braking can create excessive temperatures and boiling brake fluid, resulting in performance degradation and damage. The goal of this work is to understand brake friction performance and thermal behavior for bicycle disc brakes.
Ioan Feier, Joseph Way, Rob Redfield
doaj   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Research on Brake Disk Heat Dissipation Rib Arrangement Spacing for High-speed Railway Train

Chengshi guidao jiaotong yanjiu
Objective As the design speed of trains reaches 400 km/h level, the flow field environment under the train becomes more complex, highlighting the issues such as increased brake disc resistance and power consumption.
Yanli YAN, Haihao GU, Chun TIAN, Gengwei ZHAI   +3 more
doaj   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

ANALISIS KEAUSAN KAMPAS REM PADA DISC BRAKE DENGAN VARIASI LUBANG DISC BRAKE

JURNAL ILMIAH MOMENTUM, 2019
Disc brake merupakan salah satu komponen kendaraan bermotor yang berfungsi untuk memperlambat atau menghentikan laju kendaraan khususnya kendaraan darat yaitu sebuah besi yang berbentuk piringan yang dijepit oleh kampas rem menggunakan caliper yang digerakkan oleh piston.
Dody Samwijaya, Darmanto Darmanto, Imam Syafa’at   +2 more
openaire   +2 more sources

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

A study of commercial vehicle brake judder transmission using multi-body dynamic analysis [PDF]

, 2007
YesBraking-induced forced vibration, known as brake judder in road vehicles, causes dissatisfaction to drivers and passengers and also damage and possible early failure in components and systems. In this paper, the transmission of judder vibration from
Day, Andrew J., Hussain, Khalid, Yang, S.H.   +2 more
core   +1 more source

In Situ X‐Ray Tomography and Acoustic Emission Monitoring of Damage Evolution in C/C‐SiC Composites Fabricated by Liquid Silicon Infiltration

Advanced Science, EarlyView.
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen, Renato S. M. Almeida, Stefan Flauder, Guillaume Couégnat, Kamen Tushtev, Jürgen Horvath, Peter Wriggers, Kurosch Rezwan   +7 more
wiley   +1 more source

Status and Prospect of Thermal Analysis of Train Brake Discs

机车电传动, 2019
Disc brake is widely used for railway vehicles and cars. During the braking process, the brake disc and the brake shoe generate a large amount of heat, which affects the braking performance, so it is necessary to perform thermal analysis on the brake ...
Yuecheng NIU, Fu LI, Xinrong LI, Jincheng LI   +3 more
doaj  

Effects of material properties on generation of brake squeal noise using finite element method

Latin American Journal of Solids and Structures
This research paper is concerned with the disc brake squeal problem for passenger cars. The aim of the present research is developing a finite element model of the disc brake assembly in order to improve understanding of the influence of Young's modulus ...
Ali Belhocine, Nouby Mahdi Ghazaly
doaj   +1 more source