Results 51 to 60 of about 2,133 (267)

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

open access: yesAdvanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger   +8 more
wiley   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang   +5 more
wiley   +1 more source

Effect of Temperature Variations on Brake Squeal Characteristics in Disc Brake Systems

open access: yesEngineering Proceedings
Brake squeal is an undesirable high-frequency noise caused by vibrations induced by friction in disc brake systems. The noise is strongly affected by temperature, as this influences the material properties of the friction pair and the dynamic behaviour ...
Akif Yavuz   +3 more
doaj   +1 more source

Defining the Temperature Change of the Brake Disc

open access: yesActa Technica Jaurinensis, 2018
In the article the thermal analysis of the brake disc and separator disc of a high performance power machine will be presented. As example an agricultural vehicle with weight of 30000 kg and maximum travel speed of 40 km/h will be taken.
Melinda Menyhártné Baracskai
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Full-Scale Simulation and Experimental Study of Heat Transfer in Landing Gear Brake Discs for Medium-Sized Passenger Aircraft

open access: yesApplied Sciences
Aircraft brake discs undergo rapid temperature rises during braking, critically impacting safety, lifespan, and adjacent components. Therefore, it is particularly important to study the heat transfer mechanism during the braking process and predict the ...
Qingtang Meng   +3 more
doaj   +1 more source

Shape Optimization Design of Brake System Based on Opti Struct

open access: yesJournal of Harbin University of Science and Technology, 2018
Due to friction heat effect or severe vibration and other factors,the performance of automobile brake is insufficient,according to natural frequency theory of the principle of dynamics,Firstly,the simulation software of OptiStruct is used to analyze the ...
CHEN Zai-fa
doaj   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

open access: yesAdvanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li   +17 more
wiley   +1 more source

MODAL AND THERMAL-MECHANICAL COUPLING ANALYSIS INAUTOMOTIVE DISC BRAKE MECHANISM

open access: yesJixie qiangdu, 2017
Brake pad is vibrating when it is friction contact with the brake disc surface in automotive disc brake mechanism.When the vibration rate is close to its natural frequency of the material.
BI HouHuang   +3 more
doaj  

Investigation and Modelling of the Weight Wear of Friction Pads of a Railway Disc Brake. [PDF]

open access: yesMaterials (Basel), 2022
Sawczuk W   +4 more
europepmc   +1 more source

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