Results 41 to 50 of about 27,701 (306)

Machining strategy development in 5-axis milling operations using process models [PDF]

, 2010
Increased productivity and part quality can be achieved by selecting machining strategies and conditions properly. At one extreme very high speed and feed rate with small depth of cut can be used for high productivity whereas deep cuts accompanied with ...
Budak, Erhan, Murtezaoglu, Yavuz, Murtezaoğlu, Yavuz, Ozkirimli, Omer Mehmet, Ozturk, Erdem, Tunc, Taner L., Tunç, Taner L., Özkırımlı, Ömer Mehmet, Öztürk, Erdem   +8 more
core  

Reliability analysis of TBM disc cutters under different conditions

Underground Space, 2021
The reliability of disc cutters has a significant influence on the safety and working efficiency of tunnel boring machines (TBMs). To investigate the reliability of disc cutters under different geological and operational conditions, we conducted a series of novel rolling cutting tests on intact and jointed sandstone blocks using different dip angles ...
Liu, Bolong, Yang, Haiqing, Karekal, Shivakumar   +2 more
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

A new species of Lomanoxia Martínez from Costa Rica (Coleoptera: Scarabaeidae: Aphodiinae) [PDF]

, 2003
A new species of Lomanoxia Martínez is described from Costa Rica: L. canthonopsis Skelley and Howden. This represents the first member of the genus reported from Central America.
Howden, Henry F., Skelley, Paul E.
core  

Influence of the Rigid Connection Between Discs in the Tetrahedral Prisms on Equivalent Stresses When Cutting Work Faces [PDF]

, 2016
This paper presents the results of modeling of the stressed state of structural elements of the paired fastening points of the two disc tools to the tetrahedral prisms of the working bodies of the roadheaders of selective action when cutting work faces ...
Borisov, A. Yu., Khoreshok, Aleksey Alekseevich, Mametyev, L. E., Vorobyev, Aleksey Vasilievich   +3 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Fabrication and Evaluation of a Cabbage Harvester Prototype

Agriculture, 2020
A cabbage harvester prototype was fabricated and tested to save time, cost, and labor for harvesting. This harvester was designed for harvesting operations to drive the prototype and control the harvester.
Mohamed Ibrahim El Didamony, Ahmed Mohamed El Shal   +1 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Real-time monitoring of disc cutter wear in tunnel boring machines: A sound and vibration sensor-based approach with machine learning technique

Journal of Rock Mechanics and Geotechnical Engineering
Large portions of the tunnel boring machine (TBM) construction cost are attributed to disc cutter consumption, and assessing the disc cutter's wear level can help determine the optimal time to replace the disc cutter.
Mohammad Amir Akhlaghi, Raheb Bagherpour, Seyed Hadi Hoseinie   +2 more
doaj   +1 more source