Results 51 to 60 of about 2,788 (256)
Discrete/Finite Element Modelling of Rock Cutting with a TBM Disc Cutter [PDF]
Rock Mechanics and Rock Engineering, 2016 Peer ...
Labra, C. +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
From lab forces to field lifespans: How rock and operating parameters govern TBM disc cutter wear
Rock Mechanics BulletinTunnel boring machines (TBMs) are considered a reliable and fast method for boring long tunnels. However, the wear and failure of disc cutters in hard rock influences the efficiency of equipment, ultimate timeline, and project cost. Therefore, estimating
Ehsan Mohtarami +3 more
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Research of Chamfering Tooth Crest of Spiral Bevel Gear based on Disc Cutter
Jixie chuandong, 2018 In order to solve low accuracy and inefficiency of tooth crest chamfering for spiral bevel gear,a method of tooth crest chamfering by using disc cutter is proposed. Gear solid model with the chamfering feature is established,crest lines are used as sweep
Wei Wei, Zhang Lianhong
doaj
Advances in Civil Engineering, 2021 Hard rock Tunnel Boring Machines (TBMs) engaging disc cutters as cutting tools have been employed in considerable underground coal mines to accommodate the requirement of more stone drivage as operations are going deeper.
Gaofeng Wang, Ting Ren, Gaolei Zhu
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
工程科学学报This study addresses the abnormal failures, such as blade fractures and wear, encountered by disc cutters when excavating hard rock with high uniaxial compressive strength.
Yong SHANG +5 more
doaj +1 more source
Advances in Civil Engineering, 2019 As a key component of tunnel boring machines (TBMs), the disc cutter ring and its structural parameters are closely related to the TBM tunneling quality. Literature review shows that investigations on optimization design methods for cutter ring structure
Laikuang Lin, Yimin Xia, Dun Wu
doaj +1 more source