Results 51 to 60 of about 260,516 (241)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Rapid assembly bolt connection design method for TBM disc cutter box based on AHP

Advances in Mechanical Engineering
With the TBM disc cutter box as the subject of investigation, this study addresses the intricate and labor-intensive nature of the assembly process in TBM disc cutter box welding assembly.
Chunya Sun, Xuan Zhao, Yanqiu Xiao, Guangzhen Cui, Lianhui Jia, Shengquan Wu, Wei Zhang, Baoping Shang   +7 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

From lab forces to field lifespans: How rock and operating parameters govern TBM disc cutter wear

Rock Mechanics Bulletin
Tunnel boring machines (TBMs) are considered a reliable and fast method for boring long tunnels. However, the wear and failure of disc cutters in hard rock influences the efficiency of equipment, ultimate timeline, and project cost. Therefore, estimating
Ehsan Mohtarami, Amin Hekmatnejad, Georg H. Erharter, Alvaro Pena   +3 more
doaj   +1 more source

Experimental Study on the Evolution of Argillization of Mudstone and Cutter Wear during the TBM Tunnelling

Shock and Vibration, 2021
Argillization is a process in which clay-bearing rocks disintegrate into the clay under the action of high temperature, pressure, and water. When tunnel boring machines (TBMs) excavate in the mudstone, argillization takes place, causing the clogging of ...
Kanglei Song, Bolong Liu, Haiqing Yang
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Research of Chamfering Tooth Crest of Spiral Bevel Gear based on Disc Cutter

Jixie chuandong, 2018
In order to solve low accuracy and inefficiency of tooth crest chamfering for spiral bevel gear,a method of tooth crest chamfering by using disc cutter is proposed. Gear solid model with the chamfering feature is established,crest lines are used as sweep
Wei Wei, Zhang Lianhong
doaj  

The Influence of Confining Stresses on Rock Fragmentation, Thrust Force, and Penetration Energy in Sandstone Indentation Tests Using Disc Cutters

Advances in Civil Engineering, 2021
Hard rock Tunnel Boring Machines (TBMs) engaging disc cutters as cutting tools have been employed in considerable underground coal mines to accommodate the requirement of more stone drivage as operations are going deeper.
Gaofeng Wang, Ting Ren, Gaolei Zhu
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source